The function of the mammalian heart depends on the interplay between different cardiac cell
types. The deployment of these cells, with precise spatiotemporal regulation, is also …

The heart is lined by a single layer of mesothelial cells called the epicardium that provides
important cellular contributions for embryonic heart formation. The epicardium harbors a …

INTRODUCTION The vertebrate heart is composed of diverse cell types, all essential for
normal cardiac function. In the mouse, the earliest mesodermal progenitors of …

The sinoatrial node (SAN) is the primary pacemaker of the heart and controls heart rate
throughout life. Failure of SAN function due to congenital disease or aging results in slowing …

The cardiac conduction system (CCS) consists of distinctive components that initiate and
conduct the electrical impulse required for the coordinated contraction of the cardiac …

Understanding the origins and roles of cardiac progenitor cells is important for elucidating
the pathogenesis of congenital and acquired heart diseases,. Moreover, manipulation of …

Colony-forming units–fibroblast (CFU-Fs), analogous to those giving rise to bone marrow
(BM) mesenchymal stem cells (MSCs), are present in many organs, although the …

The mammalian heart is the first functional organ, the first indicator of life. Its normal
formation and function are essential for fetal life. Defects in heart formation lead to …

The formation of the heart is a complex morphogenetic process that depends on the
spatiotemporally regulated contribution of cardiac progenitor cells. These mainly derive from …

Pacemaker and conduction system myocytes play crucial roles in initiating and regulating
the contraction of the cardiac chambers. Genetic defects, acquired diseases, and aging …