Tertiary lymphoid structures in cancer
TN Schumacher, DS Thommen - Science, 2022 - science.org
BACKGROUND Tertiary lymphoid structures (TLSs) are organized aggregates of immune
cells that form postnatally in nonlymphoid tissues. TLSs are not found under physiological …
cells that form postnatally in nonlymphoid tissues. TLSs are not found under physiological …
B cells and tertiary lymphoid structures as determinants of tumour immune contexture and clinical outcome
B cells are a major component of the tumour microenvironment, where they are
predominantly associated with tertiary lymphoid structures (TLS). In germinal centres within …
predominantly associated with tertiary lymphoid structures (TLS). In germinal centres within …
Atlas of breast cancer infiltrated B-lymphocytes revealed by paired single-cell RNA-sequencing and antigen receptor profiling
To gain mechanistic insights into the functions and developmental dynamics of tumor-
infiltrated immune cells, especially B-lymphocytes, here we combine single-cell RNA …
infiltrated immune cells, especially B-lymphocytes, here we combine single-cell RNA …
Type I interferon in chronic virus infection and cancer
Type I interferons (IFN-Is) are emerging as key drivers of inflammation and
immunosuppression in chronic infection. Control of these infections requires IFN-I signaling; …
immunosuppression in chronic infection. Control of these infections requires IFN-I signaling; …
[PDF][PDF] Immunological responses triggered by photothermal therapy with carbon nanotubes in combination with anti‐CTLA‐4 therapy to inhibit cancer metastasis
DOI: 10.1002/adma. 201402996 subcutaneous injection, promising the use of CNTs for
cancer immunotherapy.[11] Despite the above encouraging results, whether and how CNT …
cancer immunotherapy.[11] Despite the above encouraging results, whether and how CNT …
If we build it they will come: targeting the immune response to breast cancer
Historically, breast cancer tumors have been considered immunologically quiescent, with
the majority of tumors demonstrating low lymphocyte infiltration, low mutational burden, and …
the majority of tumors demonstrating low lymphocyte infiltration, low mutational burden, and …
Tumor infiltrating lymphocytes in ovarian cancer
PP Santoiemma, DJ Powell Jr - Cancer biology & therapy, 2015 - Taylor & Francis
The accumulation of tumor infiltrating lymphocytes (TILs) in ovarian cancer is prognostic for
increased survival while increases in immunosuppressive regulatory T-cells (Tregs) are …
increased survival while increases in immunosuppressive regulatory T-cells (Tregs) are …
PD-1hi Identifies a Novel Regulatory B-cell Population in Human Hepatoma That Promotes Disease Progression
X Xiao, XM Lao, MM Chen, RX Liu, Y Wei, FZ Ouyang… - Cancer discovery, 2016 - AACR
B cells often constitute abundant cellular components in human tumors. Regulatory B cells
that are functionally defined by their ability to produce IL10 downregulate inflammation and …
that are functionally defined by their ability to produce IL10 downregulate inflammation and …
Biomarkers for immune checkpoint inhibition in sarcomas–are we close to clinical implementation?
Sarcomas are a group of diverse and complex cancers of mesenchymal origin that remains
poorly understood. Recent developments in cancer immunotherapy have demonstrated a …
poorly understood. Recent developments in cancer immunotherapy have demonstrated a …
Phase I study with ONCOS-102 for the treatment of solid tumors–an evaluation of clinical response and exploratory analyses of immune markers
T Ranki, S Pesonen, A Hemminki, K Partanen… - … for immunotherapy of …, 2016 - Springer
Background We conducted a phase I study with a granulocyte macrophage colony
stimulating factor (GMCSF)-expressing oncolytic adenovirus, ONCOS-102, in patients with …
stimulating factor (GMCSF)-expressing oncolytic adenovirus, ONCOS-102, in patients with …