Colorectal cancer (CRC) is the malignant tumor with the highest incidence in the digestive
system, and the gut microbiome plays a crucial role in CRC tumorigenesis and therapy. The …

The spatial and temporal control of bioactivity of small molecules by light
(photopharmacology) constitutes a promising approach for study of biological processes …

Herein, we report the synthesis of a series of colibactin warhead model compounds using
two newly developed metal‐free photocatalytic cyclopropanation reactions. These mild …

Although the classical Ritter reaction has been widely applied to prepare sterically hindered
amides since 1948, it has intrinsic problems, such as harsh reaction conditions, the multistep …

Colorectal cancer (CRC) is a multistage and highly heterogeneous malignant disease that
mostly occurred in aged people accompanied by microbiota alteration. Emerging evidence …

A photolabile carba (dethia) malonyl N‐acetylcysteamine derivative was devised and
prepared for the trapping of biosynthetic polyketide intermediates following light activation …