Addiction is associated with neuroplasticity in the corticostriatal brain circuitry that is
important for guiding adaptive behaviour. The hierarchy of corticostriatal information …

The metabotropic glutamate receptors (mGluRs) are family C G-protein-coupled receptors
that participate in the modulation of synaptic transmission and neuronal excitability …

OBJECTIVE: A primary behavioral pathology in drug addiction is the overpowering
motivational strength and decreased ability to control the desire to obtain drugs. In this …

Recent advances in noninvasive imaging modalities have opened endless opportunities for
molecular diagnostic and therapeutic procedures. The term “molecular imaging” is broadly …

Metabotropic glutamate (mGlu) receptors were discovered in the mid 1980s and originally
described as glutamate receptors coupled to polyphosphoinositide hydrolysis. Almost 6500 …

Rationale l-Glutamate is the major excitatory neurotransmitter in the central nervous system
(CNS) and mediates its actions via activation of both ionotropic and metabotropic receptor …

Dopamine-and cAMP-regulated phosphoprotein, Mr 32 kDa (DARPP-32), was identified
initially as a major target for dopamine and protein kinase A (PKA) in striatum. However …

G-protein-coupled receptors (GPCRs) represent one of the largest gene families in the
animal genome. These receptors can be classified into several groups based on the …

The repeated use of drugs that directly or indirectly stimulate dopamine transmission carry
addiction liability and produce enduring pathological changes in the brain circuitry that …

The past two decades have witnessed a dramatic accumulation of evidence indicating that
the excitatory amino acid glutamate plays an important role in drug addiction and …