Treatment strategies for cryptococcal infection: challenges, advances and future outlook

KR Iyer, NM Revie, C Fu, N Robbins… - Nature Reviews …, 2021 - nature.com
Cryptococcus spp., in particular Cryptococcus neoformans and Cryptococcus gattii, have an
enormous impact on human health worldwide. The global burden of cryptococcal meningitis …

[PDF][PDF] The contribution of DNA repair pathways to genome editing and evolution in filamentous pathogens

J Huang, DE Cook - FEMS Microbiology Reviews, 2022 - academic.oup.com
DNA double-strand breaks require repair or risk corrupting the language of life. To ensure
genome integrity and viability, multiple DNA double-strand break repair pathways function in …

Microbial dynamics between yeasts and acetic acid bacteria in kombucha: Impacts on the chemical composition of the beverage

T Tran, C Grandvalet, F Verdier, A Martin, H Alexandre… - Foods, 2020 - mdpi.com
Kombucha is a traditional low-alcoholic beverage made from sugared tea and transformed
by a complex microbial consortium including yeasts and acetic acid bacteria (AAB). To study …

Phylogenomics of a new fungal phylum reveals multiple waves of reductive evolution across Holomycota

LJ Galindo, P López-García, G Torruella… - Nature …, 2021 - nature.com
Compared to multicellular fungi and unicellular yeasts, unicellular fungi with free-living
flagellated stages (zoospores) remain poorly known and their phylogenetic position is often …

Exploring future applications of the apiculate yeast Hanseniaspora

N van Wyk, J Badura, C von Wallbrunn… - Critical Reviews in …, 2024 - Taylor & Francis
As a metaphor, lemons get a bad rap; however the proverb 'if life gives you lemons, make
lemonade'is often used in a motivational context. The same could be said of Hanseniaspora …

Genomic factors shape carbon and nitrogen metabolic niche breadth across Saccharomycotina yeasts

DA Opulente, AL LaBella, MC Harrison, JF Wolters… - Science, 2024 - science.org
Organisms exhibit extensive variation in ecological niche breadth, from very narrow
(specialists) to very broad (generalists). Two general paradigms have been proposed to …

UV radiation in DNA damage and repair involving DNA-photolyases and cryptochromes

YL Vechtomova, TA Telegina, AA Buglak, MS Kritsky - Biomedicines, 2021 - mdpi.com
Prolonged exposure to ultraviolet radiation on human skin can lead to mutations in DNA,
photoaging, suppression of the immune system, and other damage up to skin cancer …

Genome-scale phylogeny and contrasting modes of genome evolution in the fungal phylum Ascomycota

XX Shen, JL Steenwyk, AL LaBella, DA Opulente… - Science …, 2020 - science.org
Ascomycota, the largest and most well-studied phylum of fungi, contains three subphyla:
Saccharomycotina (budding yeasts), Pezizomycotina (filamentous fungi), and …

5-fluorocytosine resistance is associated with hypermutation and alterations in capsule biosynthesis in Cryptococcus

RB Billmyre, S Applen Clancey, LX Li… - Nature …, 2020 - nature.com
Patients infected with the fungal pathogen Cryptococcus are most effectively treated with a
combination of 5-fluorocytosine (5FC) and amphotericin B. 5FC acts as a prodrug, which is …

Balanophora genomes display massively convergent evolution with other extreme holoparasites and provide novel insights into parasite–host interactions

X Chen, D Fang, Y Xu, K Duan, S Yoshida, S Yang… - Nature Plants, 2023 - nature.com
Parasitic plants have evolved to be subtly or severely dependent on host plants to complete
their life cycle. To provide new insights into the biology of parasitic plants in general, we …