RNA-binding proteins in cancer: old players and new actors
RNA-binding proteins (RBPs) are key players in post-transcriptional events. The
combination of versatility of their RNA-binding domains with structural flexibility enables …
combination of versatility of their RNA-binding domains with structural flexibility enables …
N6-methyladenosine links RNA metabolism to cancer progression
Abstract N6-methyladenosine (m6A) is the most abundant mRNA modification. With the
development of antibody-based sequencing technologies and the findings of m6A-related …
development of antibody-based sequencing technologies and the findings of m6A-related …
CircInteractome: a web tool for exploring circular RNAs and their interacting proteins and microRNAs
Circular RNAs (circRNAs) are widely expressed in animal cells, but their biogenesis and
functions are poorly understood. CircRNAs have been shown to act as sponges for miRNAs …
functions are poorly understood. CircRNAs have been shown to act as sponges for miRNAs …
Gene expression regulation mediated through reversible m6A RNA methylation
Cellular RNAs carry diverse chemical modifications that used to be regarded as static and
having minor roles in'fine-tuning'structural and functional properties of RNAs. In this Review …
having minor roles in'fine-tuning'structural and functional properties of RNAs. In this Review …
LincRNA-p21 suppresses target mRNA translation
JH Yoon, K Abdelmohsen, S Srikantan, X Yang… - Molecular cell, 2012 - cell.com
Mammalian long intergenic noncoding RNAs (lincRNAs) are best known for modulating
transcription. Here we report a posttranscriptional function for lincRNA-p21 as a modulator of …
transcription. Here we report a posttranscriptional function for lincRNA-p21 as a modulator of …
Long noncoding RNA CCAL transferred from fibroblasts by exosomes promotes chemoresistance of colorectal cancer cells
X Deng, H Ruan, X Zhang, X Xu, Y Zhu… - … journal of cancer, 2020 - Wiley Online Library
Long noncoding RNAs (lncRNAs) are involved in the pathology of colorectal cancer (CRC).
Current efforts to eradicate CRC predominantly focused on targeting the proliferation of …
Current efforts to eradicate CRC predominantly focused on targeting the proliferation of …
Regulation of cytoplasmic mRNA decay
DR Schoenberg, LE Maquat - Nature Reviews Genetics, 2012 - nature.com
Discoveries made over the past 20 years highlight the importance of mRNA decay as a
means of modulating gene expression and thereby protein production. Up until recently …
means of modulating gene expression and thereby protein production. Up until recently …
Cancer the 'RBP'eutics–RNA-binding proteins as therapeutic targets for cancer
RNA-binding proteins (RBPs) play a critical role in the regulation of various RNA processes,
including splicing, cleavage and polyadenylation, transport, translation and degradation of …
including splicing, cleavage and polyadenylation, transport, translation and degradation of …
The RNA-binding protein HuR in human cancer: a friend or foe?
The RNA-binding proteins (RBPs) are critical trans factors that associate with specific cis
elements present in mRNAs whose stability and translation are subject to regulation. The …
elements present in mRNAs whose stability and translation are subject to regulation. The …
Insights into biological role of LncRNAs in epithelial-mesenchymal transition
Long non-coding RNAs (lncRNAs) are versatile regulators of gene expression and play
crucial roles in diverse biological processes. Epithelial-mesenchymal transition (EMT) is a …
crucial roles in diverse biological processes. Epithelial-mesenchymal transition (EMT) is a …