Hepatocellular carcinoma (HCC) is an aggressive human cancer with increasing incidence
worldwide. Multiple efforts have been made to explore pharmaceutical therapies to treat …

Dysregulation in lipid metabolism is among the most prominent metabolic alterations in
cancer. Cancer cells harness lipid metabolism to obtain energy, components for biological …

High expression of PD-L1 in tumor cells contributes to tumor immune evasion. However,
whether PD-L1 expression in tumor cells is regulated by the availability of nutrients is …

Disturbed cholesterol homeostasis plays critical roles in the development of multiple
diseases, such as cardiovascular diseases (CVD), neurodegenerative diseases and …

Autophagy is a conserved method of quality control in which cytoplasmic contents are
degraded via lysosomes. Lipophagy, a form of selective autophagy and a novel type of lipid …

Activation of receptor protein kinases is prevalent in various cancers with unknown impact
on ferroptosis. Here we demonstrated that AKT activated by insulin-like growth factor 1 …

The function of a cell is defined by its intrinsic characteristics and its niche: the tissue
microenvironment in which it dwells. Here we combine single-cell and spatial …

Metabolic associated fatty liver disease (MAFLD) encompasses a broad spectrum of hepatic
disorders, including steatosis, nonalcoholic steatohepatitis (NASH) and fibrosis. We …

Dysregulated lipid metabolism represents an important metabolic alteration in cancer. Fatty
acids, cholesterol, and phospholipid are the three most prevalent lipids that act as energy …

FTO removes the N6-methyladenosine (m6A) modification from genes and plays a critical
role in cancer development. However, the mechanisms underlying the regulation of FTO and …