Proteins are translated in the cytoplasm, but many need to access the nucleus to perform
their functions. Understanding how these nuclear proteins are transported through the …

Nuclear targeting of therapeutics provides a strategy for enhancing efficacy of molecules
active in the nucleus and minimizing off-target effects.'Active'nuclear-directed transport and …

We present the sixth report evaluating the performance of methods for predicting the atomic
resolution structures of protein complexes offered as targets to the community‐wide initiative …

The human genome encodes seven isoforms of importin α which are grouped into three
subfamilies known as α1, α2 and α3. All isoforms share a fundamentally conserved …

Nuclear translocation of the p50/p65 heterodimer is essential for NF-κB signaling. In
unstimulated cells, p50/p65 is retained by the inhibitor IκBα in the cytoplasm that masks the …

Serine/threonine protein kinase 19 (STK19) has been reported to phosphorylate and
activate oncogenic NRAS to promote melanomagenesis. However, concerns have been …

The Karyopherin-β family of proteins mediates nuclear transport of macromolecules. Nuclear
versus cytoplasmic localization of proteins is often suggested by the presence of NLSs …

Protein–protein docking is an important computational tool for predicting protein–protein
interactions. With the rapid development of proteomics projects, more and more …

Influenza A virus polymerase subunit PB2 is a major virulence determinant implicated in
pathogenicity and host adaptation. During cross-species virus transfer from avian to …

Plant intracellular nucleotide‐binding leucine‐rich repeat immune receptors (NLRs)
perceive the activity of pathogen‐secreted effector molecules that, when undetected …