Although CDKN2A is well-known as a susceptibility gene for melanoma and pancreatic
cancer, germline variants have also been anecdotally associated with a broader range of …

Background An estimated 5%–10% of all cutaneous melanoma cases occur in families. This
review describes susceptibility genes currently known to be involved in melanoma …

Background Most of large epidemiological studies on melanoma susceptibility have been
conducted on fair skinned individuals (US, Australia and Northern Europe), while Southern …

Background Mutations in the CDKN2A and CDK4 genes predispose to melanoma. From
three case-control studies of cutaneous melanoma, we estimated the prevalence and …

Malignant cutaneous melanoma (CM) is a potentially lethal form of skin cancer whose
worldwide incidence has been constantly increasing over the past decades. During their …

Background Cyclin-dependent kinase inhibitor 2A (CDKN2A) is the major high-risk
susceptibility gene for melanoma. Objective We sought to evaluate the effect of CDKN2A …

Background Multiple primary melanoma (MPM), in concert with a positive family history, is a
predictor of cyclin-dependent kinase (CDK) inhibitor 2A (CDKN2A) germline mutations. A …

Abstract Background: Inherited pathogenic variants (PVs) in the CDKN2A gene are among
the strongest known risk factors for cutaneous melanoma. Carriers are at high risks to …

Background Sarcomas are rare mesenchymal malignancies whose pathogenesis is poorly
understood; both environmental and genetic risk factors could contribute to their aetiology …

Background Several factors have been reported that influence the probability of a germline
CDKN2A mutation in a melanoma family. Our goal was to create a scoring system to …