The Drugs for Neglected Diseases initiative (DNDi) has defined and implemented an early
discovery strategy over the last few years, in fitting with its virtual R&D business model. This …

Trypanosoma cruzi and Leishmania spp. are protozoa of the Trypanosomatidae family,
being the etiological agents of two widespread parasitic diseases, Chagas disease and …

Flavonoids have previously been identified as antiparasitic agents and pteridine reductase 1
(PTR1) inhibitors. Herein, we focus our attention on the chroman-4-one scaffold. Three …

Flavonoids represent a potential source of new antitrypanosomatidic leads. Starting from a
library of natural products, we combined target-based screening on pteridine reductase 1 …

Mechanosensitive channels play important roles in the physiology of many organisms, and
their dysfunction can affect cell survival. This suggests that they might be therapeutic targets …

The species Cordia verbenacea DC (Boraginaceae), known as the whaling herb and
camaradinha, is a perennial shrub species native to the Atlantic Forest. Its leaves are used …

Leishmaniasis, Chagas disease and African sleeping sickness have been considered some
of the most important tropical protozoan afflictions. As the number of drugs currently …

Background and Methodology Recently, we reported on a new class of naphthoquinone
derivatives showing a promising anti-trypanosomatid profile in cell-based experiments. The …

Leishmaniasis and Chagas disease, caused by the kinetoplastid parasites Leishmania spp
and Trypanosoma cruzi, respectively, are among the most important parasitic diseases …

Leishmaniasis is a deadly protozoan parasitic disease affecting millions of people
worldwide. The treatment strategy of Leishmania infection depends exclusively on …