Measuring brain connectivity: diffusion tensor imaging validates resting state temporal correlations

P Skudlarski, K Jagannathan, VD Calhoun… - Neuroimage, 2008 - Elsevier
Diffusion tensor imaging (DTI) and resting state temporal correlations (RSTC) are two
leading techniques for investigating the connectivity of the human brain. They have been …

Diffusion tensor imaging analysis of sequential spreading of disease in amyotrophic lateral sclerosis confirms patterns of TDP-43 pathology

J Kassubek, HP Müller, K Del Tredici, J Brettschneider… - Brain, 2014 - academic.oup.com
Diffusion tensor imaging can identify amyotrophic lateral sclerosis-associated patterns of
brain alterations at the group level. Recently, a neuropathological staging system for …

Advanced neuroimaging approaches in amyotrophic lateral sclerosis: refining the clinical diagnosis

J Kassubek, HP Müller - Expert review of neurotherapeutics, 2020 - Taylor & Francis
Introduction: In the last decade, multiparametric magnetic resonance imaging (MRI) has
achieved tremendous advances in applications to amyotrophic lateral sclerosis (ALS) to …

To rise and to fall: functional connectivity in cognitively normal and cognitively impaired patients with Parkinson's disease

M Gorges, HP Müller, D Lulé, EH Pinkhardt… - Neurobiology of …, 2015 - Elsevier
Cognitive decline is a burdensome extra-motor symptom associated with Parkinson's
disease (PD). This study aimed at investigating intrinsic functional connectivity (iFC) of the …

A prospective harmonized multicenter DTI study of cerebral white matter degeneration in ALS

S Kalra, HP Müller, A Ishaque, L Zinman, L Korngut… - Neurology, 2020 - AAN Enterprises
Objective To evaluate progressive white matter (WM) degeneration in amyotrophic lateral
sclerosis (ALS). Methods Sixty-six patients with ALS and 43 healthy controls were enrolled …

Imaging the pathoanatomy of amyotrophic lateral sclerosis in vivo: targeting a propagation-based biological marker

J Kassubek, HP Müller, K Del Tredici, D Lulé… - Journal of Neurology …, 2018 - jnnp.bmj.com
Objective Neuropathological studies in amyotrophic lateral sclerosis (ALS) have shown a
dissemination in a regional sequence in four anatomically defined patterns. The aim of this …

Whole brain‐based analysis of regional white matter tract alterations in rare motor neuron diseases by diffusion tensor imaging

A Unrath, HP Müller, A Riecker… - Human brain …, 2010 - Wiley Online Library
Different motor neuron disorders (MNDs) are mainly defined by the clinical presentation
based on the predominance of upper or lower motor neuron impairment and the course of …

Toward diffusion tensor imaging as a biomarker in neurodegenerative diseases: technical considerations to optimize recordings and data processing

HP Müller, J Kassubek - Frontiers in Human Neuroscience, 2024 - frontiersin.org
Neuroimaging biomarkers have shown high potential to map the disease processes in the
application to neurodegenerative diseases (NDD), eg, diffusion tensor imaging (DTI). For …

Functional connectivity changes resemble patterns of pTDP-43 pathology in amyotrophic lateral sclerosis

I Schulthess, M Gorges, HP Müller, D Lulé… - Scientific reports, 2016 - nature.com
Abstract 'Resting-state'fMRI allows investigation of alterations in functional brain
organization that are associated with an underlying pathological process. We determine …

[HTML][HTML] Multiparametric microstructural MRI and machine learning classification yields high diagnostic accuracy in amyotrophic lateral sclerosis: proof of concept

TD Kocar, A Behler, AC Ludolph, HP Müller… - Frontiers in …, 2021 - frontiersin.org
The potential of multiparametric quantitative neuroimaging has been extensively discussed
as a diagnostic tool in amyotrophic lateral sclerosis (ALS). In the past, the integration of …