The resurgence of interest in anhedonia within major depression has been fuelled by
clinical trials demonstrating its utility in predicting antidepressant response as well as recent …

Despite numerous studies on the neurobiology of depression, the etiological and
pathophysiological mechanisms of this disorder remain poorly understood. A large number …

Negative symptoms have long been conceptualized as a core aspect of schizophrenia. They
play a key role in the functional outcome of the disorder, and their management represents a …

Pleasure and motivation are important factors for goal-directed behavior and well-being in
both animals and humans. Intact hedonic capacity requires an undisturbed interplay …

Humans are highly social beings, yet people with social anhedonia experience reduced
interest in or reward from social situations. Social anhedonia is a key facet of schizotypal …

Limited quantity and quality of interpersonal exchanges and relationships predict worse
symptomatic and hospitalization outcomes and limit functional recovery in people with …

Interpersonal coordination of behaviour is essential for smooth social interactions. Measures
of interpersonal behaviour, however, often rely on subjective evaluations, invasive …

Objective: Preclinical studies point to the KCNQ2/3 potassium channel as a novel target for
the treatment of depression and anhedonia, a reduced ability to experience pleasure. The …

Reliable and valid assessment of negative symptoms is crucial to further develop etiological
models and improve treatments. Our understanding of the concept of negative symptoms …

Deficits in reward and motivation are common symptoms characterizing several psychiatric
and neurological disorders. Such deficits may include anhedonia, defined as loss of …