Ligand design to acquire specificity to intended G‐quadruplex structures

S Asamitsu, T Bando… - Chemistry–A European …, 2019 - Wiley Online Library
AG‐quadruplex is a nucleic acid secondary structure that is adopted by guanine‐rich
sequences, and is considered to be relevant in various pharmacological and biological …

Developing novel G-quadruplex ligands: From interaction with nucleic acids to interfering with nucleic acid–protein interaction

ZY Sun, XN Wang, SQ Cheng, XX Su, TM Ou - Molecules, 2019 - mdpi.com
G-quadruplex is a special secondary structure of nucleic acids in guanine-rich sequences of
genome. G-quadruplexes have been proved to be involved in the regulation of replication …

RNA G-quadruplex secondary structure promotes alternative splicing via the RNA-binding protein hnRNPF

H Huang, J Zhang, SE Harvey, X Hu… - Genes & …, 2017 - genesdev.cshlp.org
It is generally thought that splicing factors regulate alternative splicing through binding to
RNA consensus sequences. In addition to these linear motifs, RNA secondary structure is …

Phase separation of heterogeneous nuclear ribonucleoprotein A1 upon specific RNA‐binding observed by magnetic resonance

I Ritsch, E Lehmann, L Emmanouilidis… - Angewandte Chemie …, 2022 - Wiley Online Library
Interaction of heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) with specific single‐
stranded RNA and its relation to liquid‐liquid phase separation (LLPS) were studied in vitro …

[HTML][HTML] Telomere-specific regulation of TERRA and its impact on telomere stability

J Rivosecchi, K Jurikova, E Cusanelli - Seminars in Cell & Developmental …, 2024 - Elsevier
TERRA is a class of telomeric repeat-containing RNAs that are expressed from telomeres in
multiple organisms. TERRA transcripts play key roles in telomere maintenance and their …

Roles of the RGG domain and RNA recognition motif of nucleolin in G-quadruplex stabilization

T Masuzawa, T Oyoshi - ACS omega, 2020 - ACS Publications
G-quadruplexes have important biologic functions that are regulated by G-quadruplex-
binding proteins. In particular, G-quadruplex structures are folded or unfolded by their …

RGG-box in hnRNPA1 specifically recognizes the telomere G-quadruplex DNA and enhances the G-quadruplex unfolding ability of UP1 domain

M Ghosh, M Singh - Nucleic acids research, 2018 - academic.oup.com
Abstract hnRNPA1 is a member of heteronuclear ribonucleoproteins that has been shown to
promote telomere elongation apart from its roles in RNA transport and alternative splicing. It …

Cooperative regulation of Zhx1 and hnRNPA1 drives the cardiac progenitor-specific transcriptional activation during cardiomyocyte differentiation

Y Chen, Y Wu, J Li, K Chen, W Wang, Z Ye… - Cell Death …, 2023 - nature.com
The zinc finger proteins (ZNFs) mediated transcriptional regulation is critical for cell fate
transition. However, it is still unclear how the ZNFs realize their specific regulatory roles in …

HnRNPA1 interacts with G-quadruplex in the TRA2B promoter and stimulates its transcription in human colon cancer cells

T Nishikawa, Y Kuwano, Y Takahara, K Nishida… - Scientific Reports, 2019 - nature.com
The human TRA2B gene consists of 10 exons and 9 introns and produces 5 splice isoforms
(TRA2β1 to TRA2β5). TRA2B exon 2 encodes multiple premature termination codons …

Structural context of a critical exon of spinal muscular atrophy gene

NN Singh, CA O'Leary, T Eich, WN Moss… - Frontiers in Molecular …, 2022 - frontiersin.org
Humans contain two nearly identical copies of Survival Motor Neuron genes, SMN1 and
SMN2. Deletion or mutation of SMN1 causes spinal muscular atrophy (SMA), one of the …