Ligand design to acquire specificity to intended G‐quadruplex structures
S Asamitsu, T Bando… - Chemistry–A European …, 2019 - Wiley Online Library
AG‐quadruplex is a nucleic acid secondary structure that is adopted by guanine‐rich
sequences, and is considered to be relevant in various pharmacological and biological …
sequences, and is considered to be relevant in various pharmacological and biological …
Developing novel G-quadruplex ligands: From interaction with nucleic acids to interfering with nucleic acid–protein interaction
ZY Sun, XN Wang, SQ Cheng, XX Su, TM Ou - Molecules, 2019 - mdpi.com
G-quadruplex is a special secondary structure of nucleic acids in guanine-rich sequences of
genome. G-quadruplexes have been proved to be involved in the regulation of replication …
genome. G-quadruplexes have been proved to be involved in the regulation of replication …
RNA G-quadruplex secondary structure promotes alternative splicing via the RNA-binding protein hnRNPF
It is generally thought that splicing factors regulate alternative splicing through binding to
RNA consensus sequences. In addition to these linear motifs, RNA secondary structure is …
RNA consensus sequences. In addition to these linear motifs, RNA secondary structure is …
Phase separation of heterogeneous nuclear ribonucleoprotein A1 upon specific RNA‐binding observed by magnetic resonance
I Ritsch, E Lehmann, L Emmanouilidis… - Angewandte Chemie …, 2022 - Wiley Online Library
Interaction of heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) with specific single‐
stranded RNA and its relation to liquid‐liquid phase separation (LLPS) were studied in vitro …
stranded RNA and its relation to liquid‐liquid phase separation (LLPS) were studied in vitro …
[HTML][HTML] Telomere-specific regulation of TERRA and its impact on telomere stability
J Rivosecchi, K Jurikova, E Cusanelli - Seminars in Cell & Developmental …, 2024 - Elsevier
TERRA is a class of telomeric repeat-containing RNAs that are expressed from telomeres in
multiple organisms. TERRA transcripts play key roles in telomere maintenance and their …
multiple organisms. TERRA transcripts play key roles in telomere maintenance and their …
Roles of the RGG domain and RNA recognition motif of nucleolin in G-quadruplex stabilization
T Masuzawa, T Oyoshi - ACS omega, 2020 - ACS Publications
G-quadruplexes have important biologic functions that are regulated by G-quadruplex-
binding proteins. In particular, G-quadruplex structures are folded or unfolded by their …
binding proteins. In particular, G-quadruplex structures are folded or unfolded by their …
RGG-box in hnRNPA1 specifically recognizes the telomere G-quadruplex DNA and enhances the G-quadruplex unfolding ability of UP1 domain
M Ghosh, M Singh - Nucleic acids research, 2018 - academic.oup.com
Abstract hnRNPA1 is a member of heteronuclear ribonucleoproteins that has been shown to
promote telomere elongation apart from its roles in RNA transport and alternative splicing. It …
promote telomere elongation apart from its roles in RNA transport and alternative splicing. It …
Cooperative regulation of Zhx1 and hnRNPA1 drives the cardiac progenitor-specific transcriptional activation during cardiomyocyte differentiation
Y Chen, Y Wu, J Li, K Chen, W Wang, Z Ye… - Cell Death …, 2023 - nature.com
The zinc finger proteins (ZNFs) mediated transcriptional regulation is critical for cell fate
transition. However, it is still unclear how the ZNFs realize their specific regulatory roles in …
transition. However, it is still unclear how the ZNFs realize their specific regulatory roles in …
HnRNPA1 interacts with G-quadruplex in the TRA2B promoter and stimulates its transcription in human colon cancer cells
T Nishikawa, Y Kuwano, Y Takahara, K Nishida… - Scientific Reports, 2019 - nature.com
The human TRA2B gene consists of 10 exons and 9 introns and produces 5 splice isoforms
(TRA2β1 to TRA2β5). TRA2B exon 2 encodes multiple premature termination codons …
(TRA2β1 to TRA2β5). TRA2B exon 2 encodes multiple premature termination codons …
Structural context of a critical exon of spinal muscular atrophy gene
Humans contain two nearly identical copies of Survival Motor Neuron genes, SMN1 and
SMN2. Deletion or mutation of SMN1 causes spinal muscular atrophy (SMA), one of the …
SMN2. Deletion or mutation of SMN1 causes spinal muscular atrophy (SMA), one of the …