Age-related hearing loss (ARHL) is the most prevalent sensory deficit in the elderly. This
progressive hearing impairment leads to social isolation and is also associated with …

Genome-wide association studies have greatly improved our understanding of the genetic
basis of disease risk. The fact that they tend not to identify more than a fraction of the specific …

For most human complex diseases and traits, SNPs identified by genome-wide association
studies (GWAS) explain only a small fraction of the heritability. Here we report a user-friendly …

Asthma and allergy are common conditions with complex etiologies involving both genetic
and environmental contributions. Recent genome‐wide association studies (GWAS) and …

Enormous progress in mapping complex traits in humans has been made in the last 5 yr.
There has been early success for prevalent diseases with complex phenotypes. These …

Background Genome-wide association studies (GWAS) based on linkage disequilibrium
(LD) provide a promising tool for the detection and fine mapping of quantitative trait loci …

We introduce ggbio, a new methodology to visualize and explore genomics annotationsand
high-throughput data. The plots provide detailed views of genomic regions, summary views …

Low back pain is a highly prevalent, chronic, and costly medical condition predominantly
triggered by intervertebral disc degeneration (IDD). IDD is often caused by structural and …

The ratio of false-positive to false-negative findings (FP: FN ratio) is an informative metric
that warrants further evaluation. The FP: FN ratio varies greatly across different …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …