Youth depression has been associated with heterogenous patterns of aberrant brain
connectivity. To make sense of these divergent findings, we conducted a systematic review …

Over the last 15 years, the field of neuroscience has evolved toward recognizing the critical
role of astroglia in shaping neuronal synaptic activity and along with the pre-and …

Psychiatric disorders share neurobiology and frequently co-occur. This neurobiological and
clinical overlap highlights opportunities for transdiagnostic treatments. In this study, we used …

Depression is frequent in older individuals and is often associated with cognitive impairment
and increasing risk of subsequent dementia. Late-life depression (LLD) has a negative …

Background Numerous studies have established the presence of gray matter atrophy and
brain activation abnormalities during neurocognitive and social cognitive tasks in …

Background Most patients with late-life depression (LLD) have cognitive impairment, and at
least one-third meet diagnostic criteria for mild cognitive impairment (MCI), a prodrome to …

Substance use disorders are associated with neuroimaging abnormalities, but results are
heterogeneous across studies and vary across substances, and the causal interpretation of …

Background Major depressive disorder (MDD) is a highly heterogeneous disease, which
brings great difficulties to clinical diagnosis and therapy. Its mechanism is still unknown …

Major depressive disorder (MDD) represents the leading cause of mental health disability for
young people worldwide but remains poorly understood. Previous neuroimaging research …

Background Youth with a family history of bipolar disorder (BD) may be at increased risk for
mood disorders and for developing side effects after antidepressant exposure. The …