The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and
hyperactivation, highlights the potential of immune renormalization as a promising strategy …

T cell lineages are defined by specialized functions and differential expression of surface
antigens, cytokines and transcription factors. Conventional CD4+ and CD8+ T cells are the …

T cells of the γδ lineage are unconventional T cells with functions not restricted to MHC-
mediated antigen presentation. Because of their broad antigen specificity and NK-like …

Metabolic programming controls immune cell lineages and functions, but little is known
about γδ T cell metabolism. Here, we found that γδ T cell subsets making either interferon-γ …

The notion of “immune privilege” of the brain has been revised to accommodate its
infiltration, at steady state, by immune cells that participate in normal neurophysiology …

Crohn's disease (CD) is a chronic relapsing disorder of the gastrointestinal tract and
represents one of the main entities of inflammatory bowel disease (IBD). CD affects …

BACKGROUND Innate lymphoid cells (ILCs) are a growing family of immune cells that mirror
the phenotypes and functions of T cells. Natural killer (NK) cells can be considered the …

Interleukin-22 (IL-22) is a recently described IL-10 family cytokine that is produced by T
helper (Th) 17 cells, γδ T cells, NKT cells, and newly described innate lymphoid cells (ILCs) …

Abstract γδ T cells are a unique and conserved population of lymphocytes that have been
the subject of a recent explosion of interest owing to their essential contributions to many …

Many body surfaces harbor organ-specific γδ T cell compartments that contribute to tissue
integrity. Thus, murine dendritic epidermal T cells (DETCs) uniquely expressing T cell …