γδ T cells: origin and fate, subsets, diseases and immunotherapy
Y Hu, Q Hu, Y Li, L Lu, Z Xiang, Z Yin… - … and Targeted Therapy, 2023 - nature.com
The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and
hyperactivation, highlights the potential of immune renormalization as a promising strategy …
hyperactivation, highlights the potential of immune renormalization as a promising strategy …
Thymic development of unconventional T cells: how NKT cells, MAIT cells and γδ T cells emerge
DG Pellicci, HF Koay, SP Berzins - Nature Reviews Immunology, 2020 - nature.com
T cell lineages are defined by specialized functions and differential expression of surface
antigens, cytokines and transcription factors. Conventional CD4+ and CD8+ T cells are the …
antigens, cytokines and transcription factors. Conventional CD4+ and CD8+ T cells are the …
Function of γδ T cells in tumor immunology and their application to cancer therapy
T cells of the γδ lineage are unconventional T cells with functions not restricted to MHC-
mediated antigen presentation. Because of their broad antigen specificity and NK-like …
mediated antigen presentation. Because of their broad antigen specificity and NK-like …
Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments
N Lopes, C McIntyre, S Martin, M Raverdeau… - Nature …, 2021 - nature.com
Metabolic programming controls immune cell lineages and functions, but little is known
about γδ T cell metabolism. Here, we found that γδ T cell subsets making either interferon-γ …
about γδ T cell metabolism. Here, we found that γδ T cell subsets making either interferon-γ …
Meningeal γδ T cell–derived IL-17 controls synaptic plasticity and short-term memory
M Ribeiro, HC Brigas, M Temido-Ferreira… - Science …, 2019 - science.org
The notion of “immune privilege” of the brain has been revised to accommodate its
infiltration, at steady state, by immune cells that participate in normal neurophysiology …
infiltration, at steady state, by immune cells that participate in normal neurophysiology …
Role of the IL23/IL17 Pathway in Crohn's Disease
H Schmitt, MF Neurath, R Atreya - Frontiers in Immunology, 2021 - frontiersin.org
Crohn's disease (CD) is a chronic relapsing disorder of the gastrointestinal tract and
represents one of the main entities of inflammatory bowel disease (IBD). CD affects …
represents one of the main entities of inflammatory bowel disease (IBD). CD affects …
Innate lymphoid cells: a new paradigm in immunology
G Eberl, M Colonna, JP Di Santo, ANJ McKenzie - Science, 2015 - science.org
BACKGROUND Innate lymphoid cells (ILCs) are a growing family of immune cells that mirror
the phenotypes and functions of T cells. Natural killer (NK) cells can be considered the …
the phenotypes and functions of T cells. Natural killer (NK) cells can be considered the …
Interleukin-22: immunobiology and pathology
JA Dudakov, AM Hanash… - Annual review of …, 2015 - annualreviews.org
Interleukin-22 (IL-22) is a recently described IL-10 family cytokine that is produced by T
helper (Th) 17 cells, γδ T cells, NKT cells, and newly described innate lymphoid cells (ILCs) …
helper (Th) 17 cells, γδ T cells, NKT cells, and newly described innate lymphoid cells (ILCs) …
Six-of-the-best: unique contributions of γδ T cells to immunology
P Vantourout, A Hayday - Nature Reviews Immunology, 2013 - nature.com
Abstract γδ T cells are a unique and conserved population of lymphocytes that have been
the subject of a recent explosion of interest owing to their essential contributions to many …
the subject of a recent explosion of interest owing to their essential contributions to many …
Epithelia use butyrophilin-like molecules to shape organ-specific γδ T cell compartments
RDM Barros, NA Roberts, RJ Dart, P Vantourout… - Cell, 2016 - cell.com
Many body surfaces harbor organ-specific γδ T cell compartments that contribute to tissue
integrity. Thus, murine dendritic epidermal T cells (DETCs) uniquely expressing T cell …
integrity. Thus, murine dendritic epidermal T cells (DETCs) uniquely expressing T cell …