Repair of DNA damage is a critical survival mechanism that affects susceptibility to various
human diseases and represents a key target for cancer therapy. A major barrier to applying …

Despite the long history of nanoparticulate calcium phosphate (CaP) as a non-viral
transfection agent, there has been limited success in attempts to optimize its properties for …

Background Calcium phosphate mediated transfection has been used for delivering DNA
into mammalian cells in excess of 30 years due to its most low cost for introducing …

MicroRNAs effectively modulate protein expression and cellular response. Unfortunately, the
lack of robust nonviral delivery platforms has limited the therapeutic application of …

During development, neurons are constantly refining their connections in response to
changes in activity. Experience-dependent plasticity is a key form of synaptic plasticity …

Axons damaged by traumatic injuries are often unable to spontaneously regenerate in the
adult central nervous system (CNS). Although the peripheral nervous system (PNS) has …

Within the brain, traumatic brain injury (TBI) alters synaptic plasticity and increases
neuroinflammation and neuronal death. Yet, there lacks effective TBI treatments providing …

Peroxisomes are highly dynamic subcellular compartments with important functions in lipid
and ROS metabolism. Impaired peroxisomal function can lead to severe metabolic disorders …

Postsynaptic density 95 (PSD-95) is a major synaptic scaffolding protein that plays a key role
in bidirectional synaptic plasticity, which is a process important for learning and memory. It is …

The cleavage of amyloid precursor protein (APP) by β-site APP cleaving enzyme 1 (BACE1)
is the rate-limiting step in beta amyloid generation during Alzheimer's disease (AD) …