Neuropathic pain, a disease of the somatosensory nervous system, afflicts many individuals
and adequate management with current pharmacotherapies remains elusive. The …

Mesenchymal stem/stromal cells (MSCs) are multipotent progenitor cells of mesodermal
origin. Due to their capacity for self‐renewal and differentiation into several cell types, MSCs …

Satellite glial cells (SGCs) surrounding the neuronal somas in peripheral sensory ganglia
are sensitive to neuronal stressors, which induce their reactive state. It is believed that such …

Neuropathic pain is usually caused by injury or dysfunction of the somatosensory system,
and medicine is a common way of treatment. Currently, there are still no satisfactory drugs …

Background The blood-nerve and myelin barrier shield peripheral neurons and their axons.
These barriers are sealed by tight junction proteins, which control the passage of potentially …

Neuropathic pain induces changes in neuronal excitability and synaptic connectivity in deep
layers of the anterior cingulate cortex (ACC) that play a central role in the sensory, emotional …

Abstract The International Association for the Study of Pain defines neuropathic pain as
“pain arising as a direct consequence of a lesion or disease affecting the somatosensory …

Sex differences in analgesic effects have gradually attracted public attention in preclinical
and clinical studies. Both human and animal females are more sensitive to cannabinoid …

Zerumbone has shown great potential in various pathophysiological models of diseases,
particularly in neuropathic pain conditions. Further understanding the mechanisms of action …

Zerumbone, a monocyclic sesquiterpene from the wild ginger plant Zingiber zerumbet (L.)
Smith, attenuates allodynia and hyperalgesia. Currently, its mechanisms of action in …