Recent advances in mass spectrometry-based structural elucidation techniques

X Ma - Molecules, 2022 - mdpi.com
Mass spectrometry (MS) has become the central technique that is extensively used for the
analysis of molecular structures of unknown compounds in the gas phase. It manipulates the …

Ion‐molecule reactions of mass‐selected ions

K Parker, NE Bollis, V Ryzhov - Mass Spectrometry Reviews, 2024 - Wiley Online Library
Gas‐phase reactions of mass‐selected ions with neutrals covers a very broad area of
fundamental and applied mass spectrometry (MS). Oftentimes, ion‐molecule reactions (IMR) …

Molecular basis for the remarkably different gas-phase behavior of deprotonated thyroid hormones triiodothyronine (T3) and reverse triiodothyronine (rT3): a clue for …

D Corinti, B Chiavarino, M Spano, A Tintaru… - Analytical …, 2021 - ACS Publications
Thyroid hormones are biologically active small molecules responsible for growth and
development regulation, basal metabolic rate, and lipid and carbohydrate metabolism …

Experimental Characterization of the Isomer-Selective Generation of the Astrochemically Relevant Hydroxymethylene Radical Cation (HCOH•+/DCOH•+)

V Richardson, L Alcock, N Solem… - The Journal of …, 2024 - ACS Publications
Interest in the observation and characterization of organic isomers in astronomical
environments has grown rapidly with an increase in the sensitivity of detection techniques …

Application of Laser-Induced Acoustic Desorption for Molecular Rotational Resonance Spectroscopy

CER Rowell, J Kaur, Y Zhang, KZ Alzarieni… - Analytical …, 2024 - ACS Publications
Molecular Rotational Resonance (MRR) spectroscopy is a uniquely precise tool for the
determination of molecular structures of volatile compounds in mixtures, as the characteristic …

Gas-Phase Alcoholysis of Benzylic Halides in the Atmospheric Pressure Ionization Source

S Shen, Y Chai, H Feng, Y Chen… - Journal of the American …, 2024 - ACS Publications
The present study investigates the gas-phase alcoholysis reaction of benzylic halides under
atmospheric pressure chemical ionization (APCI) conditions. The APCI corona discharge is …

A fixed‐charge model of the N‐protomer of 4‐aminobenzoic acid to facilitate the study of the unimolecular and bimolecular chemistry of its “neutral” carboxylic acid …

B Zhang, L Burchill, WAO Altalhi, HZ Ma… - … in Mass Spectrometry, 2024 - Wiley Online Library
Rationale There are a growing number of examples of protomers formed via electrospray
ionization (ESI) that do not fragment under mobile proton conditions, giving rise to distinct …

A Diagnostic Nitrosamine Detection Approach for Pharmaceuticals by Using Tandem Mass Spectrometry Based on Diagnostic Gas-Phase Ion-Molecule Reactions

JKY Liu, E Feng, Y Fu, W Li, X Ma, H Sheng… - Analytical …, 2022 - ACS Publications
N-Nitrosamines are strictly regulated in pharmaceutical products due to their carcinogenic
nature. Therefore, the ability to rapidly and reliably identify the N-nitroso functionality is …

Pharmacological Potential of Sulindac and Its Active Metabolite: A Comprehensive Review

SM Gupta, A Behera, S Singh - Current Drug Therapy, 2024 - benthamdirect.com
In this review, we describe and discuss the pharmaceutical aspects, pharmacokinetic profile,
and preclinical and clinical studies of sulindac and its active metabolite and emphasise their …

Differentiation of the Aziridine Functionality from Related Functional Groups in Protonated Analytes by Using Selective Ion-Molecule Reactions Followed by Collision …

RO Anyaeche, KZ Alzarieni, R Kumar… - The Journal of …, 2023 - ACS Publications
Aziridines are commonly used as reagents for the synthesis of drug substances although
they are potentially mutagenic and genotoxic. Therefore, their unambiguous detection is …