Neuroinflammation and Parkinson's disease—From neurodegeneration to therapeutic opportunities
B Araújo, R Caridade-Silva, C Soares-Guedes… - Cells, 2022 - mdpi.com
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder
worldwide. Clinically, it is characterized by a progressive degeneration of dopaminergic …
worldwide. Clinically, it is characterized by a progressive degeneration of dopaminergic …
[HTML][HTML] Understanding the contributions of VPS35 and the retromer in neurodegenerative disease
ET Williams, X Chen, PA Otero, DJ Moore - Neurobiology of disease, 2022 - Elsevier
Perturbations of the endolysosomal pathway have been suggested to play an important role
in the pathogenesis of several neurodegenerative diseases, including Parkinson's disease …
in the pathogenesis of several neurodegenerative diseases, including Parkinson's disease …
TMEM106B core deposition associates with TDP-43 pathology and is increased in risk SNP carriers for frontotemporal dementia
JD Marks, VE Ayuso, Y Carlomagno, M Yue… - Science translational …, 2024 - science.org
Genetic variation at the transmembrane protein 106B gene (TMEM106B) has been linked to
risk of frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) through an …
risk of frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) through an …
Astrocyte-derived estrogen regulates reactive astrogliosis and is neuroprotective following ischemic brain injury
Expression of the 17β-estradiol (E2) synthesis enzyme aromatase is highly upregulated in
astrocytes following brain injury. However, the precise role of astrocyte-derived E2 in the …
astrocytes following brain injury. However, the precise role of astrocyte-derived E2 in the …
TDP-43-stratified single-cell proteomics of postmortem human spinal motor neurons reveals protein dynamics in amyotrophic lateral sclerosis
A limitation of conventional bulk-tissue proteome studies in amyotrophic lateral sclerosis
(ALS) is the confounding of motor neuron (MN) signals by admixed non-MN proteins. Here …
(ALS) is the confounding of motor neuron (MN) signals by admixed non-MN proteins. Here …
Multi-omic approach characterises the neuroprotective role of retromer in regulating lysosomal health
JL Daly, CM Danson, PA Lewis, L Zhao… - Nature …, 2023 - nature.com
Retromer controls cellular homeostasis through regulating integral membrane protein
sorting and transport and by controlling maturation of the endo-lysosomal network. Retromer …
sorting and transport and by controlling maturation of the endo-lysosomal network. Retromer …
Endosomal recycling reconciles the Alzheimer's disease paradox
Endosomal recycling reconciles the Alzheimer’s disease paradox | Science Translational
Medicine news careers commentary Journals Science Science brought to you byGoogle Indexer …
Medicine news careers commentary Journals Science Science brought to you byGoogle Indexer …
Microglial VPS35 deficiency impairs Aβ phagocytosis and Aβ-induced disease-associated microglia, and enhances Aβ associated pathology
Background Vacuolar sorting protein 35 (VPS35), a key component of the retromer, plays an
essential role in selectively retrieval of transmembrane proteins from endosomes to trans …
essential role in selectively retrieval of transmembrane proteins from endosomes to trans …
VPS35 and retromer dysfunction in Parkinson's disease
J Rowlands, DJ Moore - Philosophical Transactions of …, 2024 - royalsocietypublishing.org
The vacuolar protein sorting 35 ortholog (VPS35) gene encodes a core component of the
retromer complex essential for the endosomal sorting and recycling of transmembrane …
retromer complex essential for the endosomal sorting and recycling of transmembrane …
De novo macrocyclic peptides for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex
The retromer complex (Vps35-Vps26-Vps29) is essential for endosomal membrane
trafficking and signaling. Mutation of the retromer subunit Vps35 causes late-onset …
trafficking and signaling. Mutation of the retromer subunit Vps35 causes late-onset …