Since its original identification as a leukocyte gelatinase/type V collagenase and tumour
type IV collagenase, gelatinase B/matrix metalloproteinase (MMP)-9 is now recognised as …

Myeloid sarcoma is a rare disease that can present as an isolated extramedullary leukemic
tumor, concurrently with or at relapse of acute myeloid leukemia. Owing to the rarity of this …

Hyperleukocytosis (HL) per se is a laboratory abnormality, commonly defined by a white
blood cell count> 100 000/µL, caused by leukemic cell proliferation. Not the high blood …

Up to 18% of patients with acute myeloid leukemia (AML) present with a white blood cell
(WBC) count of greater than 100,000/µL, a condition that is frequently referred to as …

Acute leukemias (both myeloid and lymphoblastic) are a group of diseases for which each
year more successful therapies are implemented. However, in a subset of cases the overall …

The biological functions of matrix metalloproteinases (MMPs) extend beyond extracellular
matrix degradation. Non‐proteolytic activities of MMPs are just beginning to be understood …

Non-proteolytic activities of matrix metalloproteinases (MMPs) have recently been shown to
impact cell migration, but the precise mechanism remains to be understood. We previously …

Nuclear membrane microdomains are proposed to act as platforms for regulation of nuclear
function, but little is known about the mechanisms controlling their formation. Organization of …

Targeted drug delivery offers an opportunity for the development of safer and more effective
therapies for the treatment of cancer. In this study, we sought to identify short, cell …

Acute myeloid leukemia (AML) is currently treated with aggressive chemotherapy that is not
well tolerated in many elderly patients, hence the unmet medical need for effective therapies …