Mesenchymal stem cells and immunomodulation: current status and future prospects

F Gao, SM Chiu, DAL Motan, Z Zhang, L Chen… - Cell death & …, 2016 - nature.com
The unique immunomodulatory properties of mesenchymal stem cells (MSCs) make them
an invaluable cell type for the repair of tissue/organ damage caused by chronic inflammation …

Manufacturing of primed mesenchymal stromal cells for therapy

JQ Yin, J Zhu, JA Ankrum - Nature biomedical engineering, 2019 - nature.com
Mesenchymal stromal cells (MSCs) for basic research and clinical applications are
manufactured and developed as unique cell products by many different manufacturers and …

Changes in phenotype and differentiation potential of human mesenchymal stem cells aging in vitro

YHK Yang, CR Ogando, C Wang See… - Stem cell research & …, 2018 - Springer
Background Adult mesenchymal stem cells (MSCs) hold great promise for regenerative
medicine because of their self-renewal, multipotency, and trophic and immunosuppressive …

Senescence in human mesenchymal stem cells: functional changes and implications in stem cell-based therapy

V Turinetto, E Vitale, C Giachino - International journal of molecular …, 2016 - mdpi.com
Regenerative medicine is extensively interested in developing cell therapies using
mesenchymal stem cells (MSCs), with applications to several aging-associated diseases …

Mesenchymal stem cell-based therapy for cardiovascular disease: progress and challenges

L Bagno, KE Hatzistergos, W Balkan, JM Hare - Molecular Therapy, 2018 - cell.com
Administration of mesenchymal stem cells (MSCs) to diseased hearts improves cardiac
function and reduces scar. These effects occur via stimulation of endogenous repair …

Advances in porous scaffold design for bone and cartilage tissue engineering and regeneration

A Cheng, Z Schwartz, A Kahn, X Li, Z Shao… - … Engineering Part B …, 2019 - liebertpub.com
Tissue engineering of bone and cartilage has progressed from simple to sophisticated
materials with defined porosity, surface features, and the ability to deliver biological factors …

Effects of oxidative stress on mesenchymal stem cell biology

RA Denu, P Hematti - Oxidative medicine and cellular longevity, 2016 - Wiley Online Library
Mesenchymal stromal/stem cells (MSCs) are multipotent stem cells present in most fetal and
adult tissues. Ex vivo culture‐expanded MSCs are being investigated for tissue repair and …

Mesenchymal stem or stromal cells: a review of clinical applications and manufacturing practices

RR Sharma, K Pollock, A Hubel, D McKenna - Transfusion, 2014 - Wiley Online Library
Mesenchymal stem cells (MSC s) have recently generated great interest in the fields of
regenerative medicine and immunotherapy due to their unique biologic properties. In this …

Nanoscale surfaces for the long-term maintenance of mesenchymal stem cell phenotype and multipotency

RJ McMurray, N Gadegaard, PM Tsimbouri… - Nature materials, 2011 - nature.com
There is currently an unmet need for the supply of autologous, patient-specific stem cells for
regenerative therapies in the clinic. Mesenchymal stem cell differentiation can be driven by …

[HTML][HTML] Co–culture systems of osteoblasts and osteoclasts: Simulating in vitro bone remodeling in regenerative approaches

G Borciani, G Montalbano, N Baldini, G Cerqueni… - Acta biomaterialia, 2020 - Elsevier
Bone is an extremely dynamic tissue, undergoing continuous remodeling for its whole
lifetime, but its regeneration or augmentation due to bone loss or defects are not always …