Air–Liquid Interface In Vitro Models for Respiratory Toxicology Research: Consensus Workshop and Recommendations

G Lacroix, W Koch, D Ritter, AC Gutleb… - Applied in vitro …, 2018 - liebertpub.com
In vitro air–liquid interface (ALI) cell culture models can potentially be used to assess
inhalation toxicology endpoints and are usually considered, in terms of relevancy, between …

[HTML][HTML] In vitro and ex vivo models in inhalation biopharmaceutical research—advances, challenges and future perspectives

MA Selo, JA Sake, KJ Kim, C Ehrhardt - Advanced Drug Delivery Reviews, 2021 - Elsevier
Oral inhalation results in pulmonary drug targeting and thereby reduces systemic side
effects, making it the preferred means of drug delivery for the treatment of respiratory …

Hazard and risk assessment of a nanoparticulate cerium oxide-based diesel fuel additive—a case study

B Park, K Donaldson, R Duffin, L Tran, F Kelly… - Inhalation …, 2008 - Taylor & Francis
Envirox is a scientifically and commercially proven diesel fuel combustion catalyst based on
nanoparticulate cerium oxide and has been demonstrated to reduce fuel consumption …

A toxicological evaluation of inhaled solid lipid nanoparticles used as a potential drug delivery system for the lung

M Nassimi, C Schleh, HD Lauenstein, R Hussein… - European Journal of …, 2010 - Elsevier
Inhalation is a non-invasive approach for both local and systemic drug delivery. This study
aimed to define the therapeutic window for solid lipid nanoparticles (SLNs) as a drug …

[PDF][PDF] In vitro models of inhalation toxicity and disease

K BeruBe, M Aufderheide, D Breheny… - … to laboratory animals, 2009 - academia.edu
Background The respiratory system represents a major portal of entry for xenobiotics into the
body, whether they be intentionally administered as in the case of drugs and anaesthetics …

Toxicity Assessment of Industrial Chemicals and Airborne Contaminants: Transition from In Vivo to In Vitro Test Methods: A Review

S Bakand, C Winder, C Khalil, A Hayes - Inhalation toxicology, 2005 - Taylor & Francis
Exposure to occupational and environmental contaminants is a major contributor to human
health problems. Inhalation of gases, vapors, aerosols, and mixtures of these can cause a …

Precision cut lung slices as an efficient tool for in vitro lung physio-pharmacotoxicology studies

JP Morin, JM Baste, A Gay, C Crochemore… - Xenobiotica, 2013 - Taylor & Francis
1. We review the specific approaches for lung tissue slices preparation and incubation
systems and the research application fields in which lung slices proved to be a very efficient …

In vitro exposures in diesel exhaust atmospheres: resuspension of PM from filters versus direct deposition of PM from air

KM Lichtveld, SM Ebersviller, KG Sexton… - … science & technology, 2012 - ACS Publications
One of the most widely used in vitro particulate matter (PM) exposures methods is the
collection of PM on filters, followed by resuspension in a liquid medium, with subsequent …

In vitro lung slices: a powerful approach for assessment of lung pathophysiology

TA Liberati, MR Randle, LA Toth - Expert review of molecular …, 2010 - Taylor & Francis
This review summarizes the existing literature on the use of in vitro lung slices to study
pulmonary physiology, pharmacology, pathogenesis and toxicity. Since in vitro lung slices …

Direct exposure methods for testing native atmospheres

M Aufderheide - Experimental and Toxicologic Pathology, 2005 - Elsevier
In vitro studies of adverse cellular effects induced by inhalable substances face a number of
problems due to the difficulties in exposing cultured cells of the respiratory tract directly to …