Engineering vaccine-based therapeutics for infectious diseases is highly challenging, as
trial formulations are often found to be nonspecific, ineffective, thermally or hydrolytically …

Most traditional vaccines are composed either of a whole pathogen or its parts; these
vaccines, however, are not always effective and can even be harmful. As such, additional …

Prophylactic vaccines have evolved from traditional whole-cell vaccines to safer subunit
vaccines. However, subunit vaccines still face problems, such as poor immunogenicity and …

As vaccine formulations have progressed from including live or attenuated strains of
pathogenic components for enhanced safety, developing new adjuvants to more effectively …

Vaccine developmental strategies are utilizing antigens encapsulated in biodegradable
polymeric nanoparticles. Here, we developed a Chlamydia nanovaccine (PLGA-rMOMP) by …

Pertussis, caused by the gram-negative bacterium Bordetella pertussis, is a highly
contagious respiratory disease. Intranasal vaccination is an ideal strategy to prevent …

Background. Layered double hydroxide (LDH) has been demonstrated as a highly efficient
antigen platform to induce effective and durable immune response. However, whether LDH …

Despite wide vaccination coverage with efficacious vaccines, pertussis is still not under
control in any country. Two types of vaccines are available for the primary vaccination series …

Developing effective mucosal subunit vaccine for the Streptococcus pneumoniae has been
unsuccessful mainly because of their poor immunogenicity with insufficient memory T and B …

Pseudomonas aeruginosa is the major infectious agent of concern for cystic fibrosis (CF)
patients. Therefore, it is necessary to develop appropriate strategies for preventing …