Solid organ transplantation is a curative therapy for hundreds of thousands of patients with
end-stage organ failure. However, long-term outcomes have not improved, and nearly half of …

Production of de novo donor-specific antibodies (dnDSA) is a major risk factor for acute and
chronic antibody-mediated rejection and graft loss after all solid organ transplantation. In this …

Background B cells produce alloantibodies and activate alloreactive T cells, negatively
affecting kidney transplant survival. By contrast, regulatory B cells are associated with …

The efficacy of bortezomib monotherapy in desensitizing kidney transplant candidates with
preformed donor-specific antibodies remains unclear. We evaluated the effect of bortezomib …

Background Patients with broad HLA sensitization have poor access to donor organs, high
mortality while waiting for kidney transplant, and inferior graft survival. Although …

Introduction Kidney transplant rejection remains an important clinical problem despite the
development of effective immunosuppressive therapy. Two major types of rejection are …

The contribution of B cells to alloimmune responses is gradually being understood in more
detail. We now know that B cells can perpetuate alloimmune responses in multiple ways:(i) …

Allograft rejection remains the major hurdle in lung transplantation despite modern
immunosuppressive treatment. As part of the alloreactive process, B cells are increasingly …

Crosstalk between B and T cells in transplantation is increasingly recognized as being
important in the alloimmune response. T cell activation of B cells occurs by a 3-stage …

B cell responses underlie the most vexing immunological barriers to organ transplantation.
Much has been learned about the molecular mechanisms of B cell responses to antigen and …