Signaling pathways activated by daunorubicin
G Laurent, JP Jaffrézou - Blood, The Journal of the American …, 2001 - ashpublications.org
The anthracycline daunorubicin is widely used in the treatment of acute nonlymphocytic
leukemia. The drug has, of course, been the object of intense basic research, as well as …
leukemia. The drug has, of course, been the object of intense basic research, as well as …
Glucosylceramide and galactosylceramide, small glycosphingolipids with significant impact on health and disease
S Reza, M Ugorski, J Suchański - Glycobiology, 2021 - academic.oup.com
Numerous clinical observations and exploitation of cellular and animal models indicate that
glucosylceramide (GlcCer) and galactosylceramide (GalCer) are involved in many …
glucosylceramide (GlcCer) and galactosylceramide (GalCer) are involved in many …
Glucosylsphingosine is a key biomarker of Gaucher disease
V Murugesan, WL Chuang, J Liu… - American journal of …, 2016 - Wiley Online Library
Gaucher disease (GD) involves the accumulation of glucosylceramide (GL1) and its
deacylated lysolipid, glucosylsphingosine (lyso‐GL1) which is implicated in mediating …
deacylated lysolipid, glucosylsphingosine (lyso‐GL1) which is implicated in mediating …
Glucocerebrosidase gene-deficient mouse recapitulates Gaucher disease displaying cellular and molecular dysregulation beyond the macrophage
In nonneuronopathic type 1 Gaucher disease (GD1), mutations in the glucocerebrosidase
gene (GBA1) gene result in glucocerebrosidase deficiency and the accumulation of its …
gene (GBA1) gene result in glucocerebrosidase deficiency and the accumulation of its …
Inhibition of glucosylceramide accumulation results in effective blockade of polycystic kidney disease in mouse models
TA Natoli, LA Smith, KA Rogers, B Wang… - Nature medicine, 2010 - nature.com
Polycystic kidney disease (PKD) represents a family of genetic disorders characterized by
renal cystic growth and progression to kidney failure. No treatment is currently available for …
renal cystic growth and progression to kidney failure. No treatment is currently available for …
Glucosylsphingosine accumulation in tissues from patients with Gaucher disease: correlation with phenotype and genotype
E Orvisky, JK Park, ME LaMarca, EI Ginns… - Molecular genetics and …, 2002 - Elsevier
Gaucher disease, the inherited deficiency of lysosomal glucocerebrosidase, presents with a
wide spectrum of clinical manifestations including neuronopathic and non-neuronopathic …
wide spectrum of clinical manifestations including neuronopathic and non-neuronopathic …
Expression of glucosylceramide synthase, converting ceramide to glucosylceramide, confers adriamycin resistance in human breast cancer cells
YY Liu, TY Han, AE Giuliano, MC Cabot - Journal of Biological Chemistry, 1999 - ASBMB
Multidrug-resistant cancer cells display elevated levels of glucosylceramide (Lavie, Y., Cao,
HT, Volner, A., Lucci, A., Han, TY, Geffen, V., Giuliano, AE, and Cabot, MC (1997) J. Biol …
HT, Volner, A., Lucci, A., Han, TY, Geffen, V., Giuliano, AE, and Cabot, MC (1997) J. Biol …
Sphingosine mediates the immediate negative inotropic effects of tumor necrosis factor-α in the adult mammalian cardiac myocyte
H Oral, GW Dorn, DL Mann - Journal of Biological Chemistry, 1997 - ASBMB
To determine whether activation of the neutral sphingomyelinase pathway was responsible
for the immediate (< 30 min) negative inotropic effects of tumor necrosis factor-α (TNF-α), we …
for the immediate (< 30 min) negative inotropic effects of tumor necrosis factor-α (TNF-α), we …
Improved inhibitors of glucosylceramide synthase
A Abe, J Inokuchi, M Jimbo, H Shimeno… - The Journal of …, 1992 - academic.oup.com
An inhibitor of glucosylceramide (GlcCer) synthase, l-phenyl-2-decanoylamino-3-
morpholino-1-propanol (PDMP), has been reported to deplete cells and mice of their …
morpholino-1-propanol (PDMP), has been reported to deplete cells and mice of their …
pH-dissociation characteristics of cardiolipin and its 2′-deoxy analogue
M Kates, JY Syz, D Gosser, TH Haines - Lipids, 1993 - Springer
Cardiolipin (CL) is found in inner mitochondrial membranes and the plasma membrane of
aerobic prokaryotes. CL is tightly bound to those transmembrane enzymes associated with …
aerobic prokaryotes. CL is tightly bound to those transmembrane enzymes associated with …