Filovirus pathogenesis and immune evasion: insights from Ebola virus and Marburg virus
I Messaoudi, GK Amarasinghe, CF Basler - Nature Reviews …, 2015 - nature.com
Ebola viruses and Marburg viruses, members of the filovirus family, are zoonotic pathogens
that cause severe disease in people, as highlighted by the latest Ebola virus epidemic in …
that cause severe disease in people, as highlighted by the latest Ebola virus epidemic in …
Human fatal zaire ebola virus infection is associated with an aberrant innate immunity and with massive lymphocyte apoptosis
N Wauquier, P Becquart, C Padilla… - PLoS neglected …, 2010 - journals.plos.org
Background Ebolavirus species Zaire (ZEBOV) causes highly lethal hemorrhagic fever,
resulting in the death of 90% of patients within days. Most information on immune responses …
resulting in the death of 90% of patients within days. Most information on immune responses …
Porcine reproductive and respiratory syndrome virus nonstructural protein 1β modulates host innate immune response by antagonizing IRF3 activation
Porcine reproductive and respiratory syndrome virus (PRRSV) infection of swine leads to a
serious disease characterized by a delayed and defective adaptive immune response. It is …
serious disease characterized by a delayed and defective adaptive immune response. It is …
Viral tricks to grid-lock the type I interferon system
GA Versteeg, A García-Sastre - Current opinion in microbiology, 2010 - Elsevier
Type I interferons (IFNs) play a crucial role in the innate immune avant-garde against viral
infections. Virtually all viruses have developed means to counteract the induction, signaling …
infections. Virtually all viruses have developed means to counteract the induction, signaling …
Mutual antagonism between the Ebola virus VP35 protein and the RIG-I activator PACT determines infection outcome
P Luthra, P Ramanan, CE Mire, C Weisend, Y Tsuda… - Cell host & …, 2013 - cell.com
The cytoplasmic pattern recognition receptor RIG-I is activated by viral RNA and induces
type I IFN responses to control viral replication. The cellular dsRNA binding protein PACT …
type I IFN responses to control viral replication. The cellular dsRNA binding protein PACT …
[HTML][HTML] Micronutrient selenium deficiency influences evolution of some viral infectious diseases
M Harthill - Biological trace element research, 2011 - Springer
Recently emerged viral infectious diseases (VIDs) include HIV/AIDS, influenzas H5N1 and
2009 H1N1, SARS, and Ebola hemorrhagic fevers. Earlier research determined metabolic …
2009 H1N1, SARS, and Ebola hemorrhagic fevers. Earlier research determined metabolic …
The molecular basis of viral inhibition of IRF-and STAT-dependent immune responses
The antiviral innate immunity is the first line of host defense against virus infections. In
mammalian cells, viral infections initiate the expression of interferons (IFNs) in the host that …
mammalian cells, viral infections initiate the expression of interferons (IFNs) in the host that …
Ebola virus protein VP35 impairs the function of interferon regulatory factor-activating kinases IKKε and TBK-1
KC Prins, WB Cárdenas, CF Basler - Journal of virology, 2009 - Am Soc Microbiol
ABSTRACT The Ebola virus (EBOV) VP35 protein antagonizes the early antiviral alpha/beta
interferon (IFN-α/β) response. We previously demonstrated that VP35 inhibits the virus …
interferon (IFN-α/β) response. We previously demonstrated that VP35 inhibits the virus …
Post-exposure treatments for Ebola and Marburg virus infections
RW Cross, CE Mire, H Feldmann… - Nature Reviews Drug …, 2018 - nature.com
The filoviruses—Ebola virus and Marburg virus—cause lethal haemorrhagic fever in
humans and non-human primates (NHPs). Filoviruses present a global health threat both as …
humans and non-human primates (NHPs). Filoviruses present a global health threat both as …