Nanoparticle drug delivery systems and their applications as targeted therapies for triple negative breast cancer
The therapeutic effect of highly malignant triple negative breast cancer (TNBC) is negatively
affected by the formation of tumor cell resistant clone and the severe toxicity of …
affected by the formation of tumor cell resistant clone and the severe toxicity of …
Challenges of applying multicellular tumor spheroids in preclinical phase
SJ Han, S Kwon, KS Kim - Cancer cell international, 2021 - Springer
Abstract The three-dimensional (3D) multicellular tumor spheroids (MCTs) model is
becoming an essential tool in cancer research as it expresses an intermediate complexity …
becoming an essential tool in cancer research as it expresses an intermediate complexity …
3D bioprinted vascularized tumour for drug testing
An in vitro screening system for anti-cancer drugs cannot exactly reflect the efficacy of drugs
in vivo, without mimicking the tumour microenvironment (TME), which comprises cancer …
in vivo, without mimicking the tumour microenvironment (TME), which comprises cancer …
A microfluidic spheroid culture device with a concentration gradient generator for high-throughput screening of drug efficacy
Three-dimensional (3D) cell culture is considered more clinically relevant in mimicking the
structural and physiological conditions of tumors in vivo compared to two-dimensional cell …
structural and physiological conditions of tumors in vivo compared to two-dimensional cell …
[HTML][HTML] From cell spheroids to vascularized cancer organoids: Microfluidic tumor-on-a-chip models for preclinical drug evaluations
Chemotherapy is one of the most effective cancer treatments. Starting from the discovery of
new molecular entities, it usually takes about 10 years and 2 billion US dollars to bring an …
new molecular entities, it usually takes about 10 years and 2 billion US dollars to bring an …
[HTML][HTML] Spheroid-on-chip microfluidic technology for the evaluation of the impact of continuous flow on metastatic potential in cancer models in vitro
T Collins, E Pyne, M Christensen, A Iles, N Pamme… - …, 2021 - pubs.aip.org
The majority of cancer deaths are linked to tumor spread, or metastasis, but 3D in vitro
metastasis models relevant to the tumor microenvironment (including interstitial fluid flow) …
metastasis models relevant to the tumor microenvironment (including interstitial fluid flow) …
Technological advances in tumor-on-chip technology: From bench to bedside
Simple Summary Various 3D in vitro tumor models are rapidly advancing cancer research.
Unlike animal models, they can be produced quickly and are amenable to high-throughput …
Unlike animal models, they can be produced quickly and are amenable to high-throughput …
A microfluidic platform for multi-size 3D tumor culture, monitoring and drug resistance testing
W Liu, M Sun, B Lu, M Yan, K Han, J Wang - Sensors and Actuators B …, 2019 - Elsevier
The establishment of a miniaturized platform capable of microscale control for sequential,
coordinated, and throughput biomimetic tumor manipulation and analysis offer a high …
coordinated, and throughput biomimetic tumor manipulation and analysis offer a high …
Uniform tumor spheroids on surface-optimized microfluidic biochips for reproducible drug screening and personalized medicine
Spheroids are recognized for resembling the important characteristics of natural tumors in
cancer research. However, the lack of controllability of the spheroid size, form, and density in …
cancer research. However, the lack of controllability of the spheroid size, form, and density in …
Core-Crosslinked Fluorescent Worm-Like Micelles for Glucose-Mediated Drug Delivery
JK Elter, S Quader, J Eichhorn, M Gottschaldt… - …, 2021 - ACS Publications
We herein report the fabrication of core-crosslinked, fluorescent, and surface-functionalized
worm-like block copolymer micelles as drug delivery vehicles. The polyether-based diblock …
worm-like block copolymer micelles as drug delivery vehicles. The polyether-based diblock …