Emergence of antibiotic resistant pathogenic bacteria poses a serious public health
challenge worldwide. However, antibiotic resistance genes are not confined to the clinic; …

Macrolide antibiotics inhibit protein synthesis by targeting the bacterial ribosome. They bind
at the nascent peptide exit tunnel and partially occlude it. Thus, macrolides have been …

Macrolides represent a large family of protein synthesis inhibitors of great clinical interest
due to their applicability to human medicine. Macrolides are composed of a macrocyclic …

Macrolides and ketolides comprise a family of clinically important antibiotics that inhibit
protein synthesis by binding within the exit tunnel of the bacterial ribosome. While these …

Many antibiotics inhibit bacterial growth by binding to the ribosome and interfering with
protein biosynthesis. Macrolides represent one of the most successful classes of ribosome …

Antimicrobial resistance is a global challenge and the effectiveness of old antibiotics is
decreasing. Discovery and development of antibacterial agents have been accelerated to …

Genetic information is translated into proteins by the ribosome. Structural studies of the
ribosome and of its complexes with factors and inhibitors have provided invaluable …

Antibiotics can cause dormancy (bacteriostasis) or induce death (cidality) of the targeted
bacteria. The bactericidal capacity is one of the most important properties of antibacterial …

The rise of multidrug-resistant bacterial infections is a cause of global concern. There is an
urgent need to both revitalize antibacterial agents that are ineffective due to resistance while …

Background New antibiotics are urgently needed in clinical treatment of superdrug-resistant
bacteria. Nonribosomal peptides (NRPs) are a major source of antibiotics because they …