Amyloid β protein (Aβ) is the main component of neuritic plaques in Alzheimer's disease
(AD), and its accumulation has been considered as the molecular driver of Alzheimer's …

Neuroinflammation is instigated by the misfiring of immune cells in the central nervous
system (CNS) involving microglia and astrocytes as key cell-types. Neuroinflammation is a …

Ageing is characterized by the development of persistent pro-inflammatory responses that
contribute to atherosclerosis, metabolic syndrome, cancer and frailty,–. The ageing brain is …

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease worldwide,
characterized by progressive neuron degeneration or loss due to excessive accumulation of …

Alzheimer's disease (AD) is an age‐associated neurodegenerative disorder with
multifactorial etiology, intersecting genetic and environmental risk factors, and a lack of …

Recent advances highlight a pivotal role for cellular metabolism in programming immune
responses. Here, we demonstrate that cell-autonomous generation of nicotinamide adenine …

In addition to amyloid-β plaque and tau neurofibrillary tangle deposition, neuroinflammation
is considered a key feature of Alzheimer's disease pathology. Inflammation in Alzheimer's …

Microglia are the primary immune cell of the brain and function to protect the central nervous
system (CNS) from injury and invading pathogens. In the homeostatic brain, microglia serve …

The scarcity of live human brain cells for experimental access has for a long time limited our
ability to study complex human neurological disorders and elucidate basic neuroscientific …

The nervous and immune systems have evolved in parallel from the early bilaterians, in
which innate immunity and a central nervous system (CNS) coexisted for the first time, to …