Multi-omics data integration methods and their applications in psychiatric disorders
To study mental illness and health, in the past researchers have often broken down their
complexity into individual subsystems (eg, genomics, transcriptomics, proteomics, clinical …
complexity into individual subsystems (eg, genomics, transcriptomics, proteomics, clinical …
New insights into the genetic etiology of Alzheimer's disease and related dementias
Abstract Characterization of the genetic landscape of Alzheimer's disease (AD) and related
dementias (ADD) provides a unique opportunity for a better understanding of the associated …
dementias (ADD) provides a unique opportunity for a better understanding of the associated …
Cluster headache genomewide association study and meta‐analysis identifies eight loci and implicates smoking as causal risk factor
BS Winsvold, AVE Harder, C Ran… - Annals of …, 2023 - Wiley Online Library
Objective The objective of this study was to aggregate data for the first genomewide
association study meta‐analysis of cluster headache, to identify genetic risk variants, and …
association study meta‐analysis of cluster headache, to identify genetic risk variants, and …
Genetic regulation of methylation in human endometrium and blood and gene targets for reproductive diseases
Background Major challenges in understanding the functional consequences of genetic risk
factors for human disease are which tissues and cell types are affected and the limited …
factors for human disease are which tissues and cell types are affected and the limited …
Integration of methylation QTL and enhancer–target gene maps with schizophrenia GWAS summary results identifies novel genes
Motivation Most trait-associated genetic variants identified in genome-wide association
studies (GWASs) are located in non-coding regions of the genome and thought to act …
studies (GWASs) are located in non-coding regions of the genome and thought to act …
Epigenome-wide analysis identifies methylome profiles linked to obsessive-compulsive disorder, disease severity, and treatment response
Obsessive-compulsive disorder (OCD) is a prevalent mental disorder affecting~ 2–3% of the
population. This disorder involves genetic and, possibly, epigenetic risk factors. The …
population. This disorder involves genetic and, possibly, epigenetic risk factors. The …
Integrative multi-omic analysis identifies genetically influenced DNA methylation biomarkers for breast and prostate cancers
Aberrant DNA methylation has emerged as a hallmark in several cancers and contributes to
risk, oncogenesis, progression, and prognosis. In this study, we performed imputation-based …
risk, oncogenesis, progression, and prognosis. In this study, we performed imputation-based …
Psychopathy subdomains in violent offenders with and without a psychotic disorder
Background Violence in psychosis has been linked to antisocial behavior and psychopathy
traits. Psychopathy comprises aspects of interpersonal, affective, lifestyle, and antisocial …
traits. Psychopathy comprises aspects of interpersonal, affective, lifestyle, and antisocial …
Genetic regulation of DNA methylation yields novel discoveries in GWAS of colorectal cancer
Background: Colorectal cancer has a strong epigenetic component that is accompanied by
frequent DNA methylation (DNAm) alterations in addition to heritable genetic risk. It is of …
frequent DNA methylation (DNAm) alterations in addition to heritable genetic risk. It is of …
A gene-level methylome-wide association analysis identifies novel Alzheimer's disease genes
Motivation Transcriptome-wide association studies (TWAS) have successfully facilitated the
discovery of novel genetic risk loci for many complex traits, including late-onset Alzheimer's …
discovery of novel genetic risk loci for many complex traits, including late-onset Alzheimer's …