The corticostriatal pathway that carries sensory, motor, and limbic information to the striatum
plays a critical role in motor control, action selection, and reward. Dysfunction of this …

Zoonomia is the largest comparative genomics resource for mammals produced to date. By
aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect …

INTRODUCTION The brain is responsible for cognition, behavior, and much of what makes
us uniquely human. The development of the brain is a highly complex process, and this …

Neurodevelopmental disorders (NDDs) are multifaceted pathologic conditions manifested
with intellectual disability, autistic features, psychiatric problems, motor dysfunction, and/or …

DNA-binding proteins are crucial to alternative splicing, methylation, and the structural
composition of the DNA. The existing experimental methods for identifying DNA-binding …

Cortical deep projection neurons (DPNs) are implicated in neurodevelopmental disorders.
Although recent findings emphasize post-mitotic programs in projection neuron fate …

While the transcription factor NEUROD2 has recently been associated with epilepsy, its
precise role during nervous system development remains unclear. Using a multi-scale …

Autism spectrum disorder (ASD) and Alzheimer's disease (AD) are neurodevelopmental and
neurodegenerative disorders affecting two opposite ends of life span, ie, childhood and old …

This review provides an overview of the synaptic dysfunction of neuronal circuits and the
ensuing behavioral alterations caused by mutations in autism spectrum disorder (ASD) …

The urinary tract comprises the renal pelvis, the ureter, the urinary bladder, and the urethra.
The tract acts as a functional unit, first propelling urine from the kidney to the bladder, then …