Apoptosis is a form of programmed and controlled cell death that accounts for the majority of
cellular death in bioprocesses. Cell death affects culture longevity and product quality; it is …

The growing biopharmaceutical industry has reached a level of maturity that allows for the
monitoring of numerous key variables for both process characterization and outcome …

For over three decades, Chinese hamster ovary (CHO) cells have been the chosen
expression platform for the production of therapeutic proteins with complex post …

Fed‐batch Chinese hamster ovary (CHO) cell culture is the most commonly used process for
IgG production in the biopharmaceutical industry. Amino acid and glucose consumption, cell …

Cultured mammalian cells are the main workhorses for producing biologics. The
performance of these cell culture processes, in terms of both productivity and product quality …

Multivariate analysis of cell culture bioprocess data has the potential of unveiling hidden
process characteristics and providing new insights into factors affecting process …

Trace metals are supplied to chemically‐defined media (CDM) for optimal Chinese hamster
ovary (CHO) cell culture performance during the production of monoclonal antibodies and …

Chinese hamster ovary (CHO) cells in culture are known to consume large amounts of
nutrients and divert most of them toward byproducts, some of which, including lactate and …

Highlights•Proliferating mammalian cultures exhibit 'wasteful'glucose and glutamine
metabolism.•Stationary cultures shift to oxidative phosphorylation and reduce lactate …

Mammalian cell cultures typically exhibit an energy inefficient phenotype characterized by
the consumption of large quantities of glucose and the concomitant production of large …