Immune checkpoint inhibitors: basics and challenges

B Li, HL Chan, P Chen - Current medicinal chemistry, 2019 - ingentaconnect.com
Cancer is one of the most deadly diseases in the modern world. The last decade has
witnessed dramatic advances in cancer treatment through immunotherapy. One extremely …

Vaccine adjuvants: role and mechanisms of action in vaccine immunogenicity

DJ Marciani - Drug discovery today, 2003 - Elsevier
Inactivated vaccines require adjuvants to stimulate an immune response. The choice of
adjuvant or immune enhancer determines whether the immune response is effective …

Compensatory upregulation of PD-1, LAG-3, and CTLA-4 limits the efficacy of single-agent checkpoint blockade in metastatic ovarian cancer

RY Huang, A Francois, AJR McGray, A Miliotto… - …, 2017 - Taylor & Francis
Tumor-associated or-infiltrating lymphocytes (TALs or TILs) co-express multiple immune
inhibitory receptors that contribute to immune suppression in the ovarian tumor …

Persistent luminescence immune hydrogel for photodynamic‐immunotherapy of tumors in vivo

G Shu, W Zhu, Y Jiang, X Li, J Pan… - Advanced Functional …, 2021 - Wiley Online Library
Persistent luminescence material (PLM)‐based photodynamic therapy (PDT) has shown
tremendous promise in tumor elimination via avoiding continuous external light illumination …

Inhibition of T cell and natural killer cell function by adenosine and its contribution to immune evasion by tumor cells

DW Hoskin, JS Mader, SJ Furlong… - International …, 2008 - spandidos-publications.com
The resistance of many human cancers to immune-based therapies, including adoptive
immunotherapy and the administration of therapeutic cancer vaccines, has been attributed …

Lactobacilli as live vaccine delivery vectors: progress and prospects

JFML Seegers - Trends in biotechnology, 2002 - cell.com
Evidence is accumulating that lactobacilli influence the immune response in a strain-
dependent manner. This immunomodulatory capacity is important for the development of the …

Peripherally derived T regulatory and γδ T cells have opposing roles in the pathogenesis of intractable pediatric epilepsy

D Xu, AP Robinson, T Ishii, DAS Duncan… - Journal of Experimental …, 2018 - rupress.org
The pathophysiology of drug-resistant pediatric epilepsy is unknown. Flow cytometric
analysis of inflammatory leukocytes in resected brain tissues from 29 pediatric patients with …

Immunological memory to viral infections

RM Welsh, LK Selin… - Annu. Rev. Immunol., 2004 - annualreviews.org
▪ Abstract The purpose of immunological memory is to protect the host from reinfection, to
control persistent infections, and, through maternal antibody, to protect the host's …

HIV-1 gp120 inhibits TLR9-mediated activation and IFN-α secretion in plasmacytoid dendritic cells

E Martinelli, C Cicala, D Van Ryk… - Proceedings of the …, 2007 - National Acad Sciences
Plasmacytoid dendritic cells (pDCs) play a central role in innate and adaptive immune
responses against viral infections. pDCs secrete type I IFNs and proinflammatory cytokines …

Combination immunotherapy with 4-1BB activation and PD-1 blockade enhances antitumor efficacy in a mouse model of subcutaneous tumor

Y Shindo, K Yoshimura, A Kuramasu… - Anticancer …, 2015 - ar.iiarjournals.org
Background/Aim: The purpose of the present study was to establish an effective
immunotherapy by skewing the cosignal balance to be on the positive side by using the …