Four major receptor families enable cells to respond to chemical and physical signals from
their proximal environment. The ligand-and voltage-gated ion channels, G-protein-coupled …

The classical studies of nicotine by Langley at the turn of the 20th century introduced the
concept of a “receptive substance,” from which the idea of a “receptor” came to light …

Nicotine is a highly addictive drug found in tobacco that drives its continued use despite the
harmful consequences. The initiation of nicotine abuse involves the mesolimbic dopamine …

Nicotinic acetylcholine receptors (nAChRs) belong to the “Cys-loop” superfamily of ligand-
gated ion channels that includes GABA A, glycine, and serotonin (5-HT 3) receptors. There …

Subtypes of neuronal nicotinic acetylcholine receptors (nAChRs) are constructed from
numerous subunit combinations that compose channel-receptor complexes with varied …

A full-length clone coding for the rat alpha 7 nicotinic receptor subunit was isolated from an
adult brain cDNA library and expressed in Xenopus oocytes. A significant proportion of the …

The conversion of acetylcholine binding into ion conduction across the membrane is
becoming more clearly understood in terms of the structure of the receptor and its transitions …

We report the isolation and functional characterization of a member of the nicotinic
acetylcholine receptor subunit gene family, cc9. Xenopus oocytes injected with a9 cRNA …

The behavioral and cognitive effects of nicotine suggest that nicotinic acetylcholine
receptors (nAChRs) participate in central nervous system (CNS) function. Although nAChR …

Cys-loop receptors are membrane-spanning neurotransmitter-gated ion channels that are
responsible for fast excitatory and inhibitory transmission in the peripheral and central …