Six genes confer a high risk for developing breast cancer (BRCA1/2, TP53, PTEN, STK11,
CDH1). Both BRCA1 and BRCA2 have DNA repair functions, and BRCA1/2 deficient tumors …

BRCA1 is a major breast and ovarian cancer susceptibility gene, with mutations in this gene
predisposing women to a very high risk of developing breast and ovarian tumours. BRCA1 …

Ubiquitin-mediated proteasomal degradation is an important mechanism to control protein
load in the cells. Ubiquitin binds to a protein on lysine residue and usually promotes its …

Germline mutations of the breast cancer 1 (BRCA1) gene are a major cause of familial
breast and ovarian cancer. The BRCA1 protein displays E3 ubiquitin ligase activity, and this …

Cisplatin-based chemotherapeutic regimens are the most frequently used (neo) adjuvant
treatments for the majority of solid tumors. While platinum-based chemotherapeutic …

The breast and ovarian tumor suppressor BRCA1 constitutes a RING heterodimer E3 ligase
with BARD1. BRCA1-associated protein 1 (BAP1) is a ubiquitin COOH-terminal hydrolase …

Mutations in breast cancer type 1 susceptibility protein (BRCA1) and its heterodimeric
binding partner BARD1 confer a high risk for the development of breast and ovarian …

Accumulated evidence supports that the ubiquitin proteasome pathway (UPP) plays a
crucial role in protein metabolism implicated in the regulation of many biological processes …

Abstract Background The Poly (ADP-ribose) polymerase (PARP) superfamily was originally
identified as enzymes that catalyze the attachment of ADP-ribose subunits to target proteins …

The breast cancer suppressor BRCA1 forms a stable heterodimeric E3 ubiquitin ligase with
BARD1. Each protein controls the abundance and stability of the other, and loss of the …