Rho GTPases are a family of small G proteins that regulate a wide array of cellular
processes related to their key roles controlling the cytoskeleton. Cancer is a multistep …

Helping B cells and antibody responses is a major function of CD4+ T cells. It has been 10
years since the publication of Bcl6 as the lineage-defining transcription factor for T follicular …

It has been nearly half a century since angioimmunoblastic T-cell lymphoma (AITL) was
characterized in the early 1970's. Our understanding of the disease has dramatically …

The capability to spatially explore RNA biology in formalin-fixed paraffin-embedded (FFPE)
tissues holds transformative potential for histopathology research. Here, we present …

Peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS) is a diagnosis of
exclusion, being the most common entity in mature T-cell neoplasms, and its molecular …

RhoA is a ubiquitously expressed cytoplasmic protein that belongs to the family of small
GTPases. RhoA acts as a molecular switch that is activated in response to binding of …

Abstract The Rho GTPases RhoA, Rac1, and Cdc42 are important regulators of cytoskeletal
dynamics. Although many in vitro and in vivo data indicate tumor-promoting effects of …

Angioimmunoblastic T cell lymphoma (AITL) is a peripheral T cell lymphoma that originates
from T follicular helper (Tfh) cells and exhibits a prominent tumor microenvironment (TME) …

Germinal centers (GCs) are confined anatomic regions where rapidly proliferating B cells
undergo somatic mutation and selection and eventual differentiation into memory B cells or …

Since nucleoside-modified mRNA vaccines strongly activate T follicular helper cells, it is
important to explore the possible impact of approved SARS-CoV-2 mRNA vaccines on …