The blood–brain barrier (BBB) is one of the most complex and selective barriers in the
human organism. Its role is to protect the brain and preserve the homeostasis of the central …

The blood-brain barrier (BBB) has been a great hurdle for brain drug delivery. The BBB in
healthy brain is a diffusion barrier essential for protecting normal brain function by impeding …

Stroke is a leading cause of disability worldwide, and brain injuries devastate patients and
their families, but currently no drugs on the market promote neurological recovery. Limited …

Exosomes are cell-derived vesicles containing heterogeneous active biomolecules such as
proteins, lipids, mRNAs, receptors, immune regulatory molecules, and nucleic acids. They …

The ability of cells to transmit bioactive molecules to recipient cells and the extracellular
environment is a fundamental requirement for both normal physiology and disease …

Long-and short-distance communication can take multiple forms. Among them are
exosomes and ectosomes, extracellular vesicles (EVs) released from the cell to deliver …

Purpose The blood–brain barrier (BBB) essentially restricts therapeutic drugs from entering
into the brain. This study tests the hypothesis that brain endothelial cell derived exosomes …

Introduction microRNA (miRNA) are small non-coding RNA species that are transcriptionally
processed in the host cell and released extracellularly into the bloodstream. Normally …

To develop effective disease-modifying therapies for neurodegenerative diseases, reliable
markers of diagnosis, disease activity and progression are a research priority. The fact that …

Here, we identified release of extracellular vesicles (EVs) by the choroid plexus epithelium
(CPE) as a new mechanism of blood–brain communication. Systemic inflammation induced …