Aberrant maturation and connectivity of prefrontal cortex in schizophrenia—contribution of NMDA receptor development and hypofunction

WJ Gao, SS Yang, NR Mack, LA Chamberlin - Molecular psychiatry, 2022 - nature.com
The neurobiology of schizophrenia involves multiple facets of pathophysiology, ranging from
its genetic basis over changes in neurochemistry and neurophysiology, to the systemic level …

[HTML][HTML] Glutamate in schizophrenia: Neurodevelopmental perspectives and drug development

A Egerton, AA Grace, J Stone, MG Bossong… - Schizophrenia …, 2020 - Elsevier
Research into the neurobiological processes that may lead to the onset of schizophrenia
places growing emphasis on the glutamatergic system and brain development. Preclinical …

NMDA receptor hypofunction for schizophrenia revisited: Perspectives from epigenetic mechanisms

MA Snyder, WJ Gao - Schizophrenia research, 2020 - Elsevier
Schizophrenia (SZ) is a neurodevelopmental disorder with cognitive deficits manifesting
during early stages of the disease. Evidence suggests that genetic factors in combination …

The gut microbiota promotes the pathogenesis of schizophrenia via multiple pathways

X Yuan, Y Kang, C Zhuo, XF Huang, X Song - Biochemical and biophysical …, 2019 - Elsevier
Schizophrenia is a severe mental disorder with unknown etiology. Many mechanisms,
including dysregulation of neurotransmitters, immune disturbance, and abnormal …

[HTML][HTML] The role of microbiota in the pathogenesis of schizophrenia and major depressive disorder and the possibility of targeting microbiota as a treatment option

F Lv, S Chen, L Wang, R Jiang, H Tian, J Li, Y Yao… - Oncotarget, 2017 - ncbi.nlm.nih.gov
The importance of interactions between the brain and the gastrointestinal tract has been
increasingly recognized in recent years. It has been proposed that dysregulation and …

Anti-anxiety and antidepressant-like effects of astragaloside IV and saponins extracted from Astragalus spinosus against the bisphenol A-induced motor and cognitive …

HTAE Abd Elkader, HM Abdou, OA Khamiss… - … Science and Pollution …, 2021 - Springer
Bisphenol A (BPA) is a chemical endocrine disruptor to which humans are often exposed in
daily life. Postnatal administration of BPA results in schizophrenia (SCZ)-like behaviours in …

Epigenetic mechanisms underlying NMDA receptor hypofunction in the prefrontal cortex of juvenile animals in the MAM model for schizophrenia

Y Gulchina, SJ Xu, MA Snyder… - Journal of …, 2017 - Wiley Online Library
Schizophrenia (SCZ) is characterized not only by psychosis, but also by working memory
and executive functioning deficiencies, processes that rely on the prefrontal cortex (PFC) …

Exploring the potential of probiotics and prebiotics in major depression: from molecular function to clinical therapy

X Yuan, J Chai, W Xu, Y Zhao - Probiotics and Antimicrobial Proteins, 2024 - Springer
Major depressive disorder (MDD) represents a complex and challenging mental health
condition with multifaceted etiology. Recent research exploring the gut-brain axis has shed …

A novel variant in TAF1 affects gene expression and is associated with X-linked TAF1 intellectual disability syndrome

SE Hurst, E Liktor-Busa, A Moutal, S Parker… - Neuronal …, 2018 - portlandpress.com
We investigated the genome of a 5-year-old male who presented with global developmental
delay (motor, cognitive, and speech), hypotonia, possibly ataxia, and cerebellar hypoplasia …

Juvenile treatment with mGluR2/3 agonist prevents schizophrenia-like phenotypes in adult by acting through GSK3β

B Xing, G Han, MJ Wang, MA Snyder, WJ Gao - Neuropharmacology, 2018 - Elsevier
Prodromal memory deficits represent an important marker for the development of
schizophrenia (SZ), in which glutamatergic hypofunction occurs in the prefrontal cortex …