Aberrant maturation and connectivity of prefrontal cortex in schizophrenia—contribution of NMDA receptor development and hypofunction
The neurobiology of schizophrenia involves multiple facets of pathophysiology, ranging from
its genetic basis over changes in neurochemistry and neurophysiology, to the systemic level …
its genetic basis over changes in neurochemistry and neurophysiology, to the systemic level …
[HTML][HTML] Glutamate in schizophrenia: Neurodevelopmental perspectives and drug development
Research into the neurobiological processes that may lead to the onset of schizophrenia
places growing emphasis on the glutamatergic system and brain development. Preclinical …
places growing emphasis on the glutamatergic system and brain development. Preclinical …
NMDA receptor hypofunction for schizophrenia revisited: Perspectives from epigenetic mechanisms
MA Snyder, WJ Gao - Schizophrenia research, 2020 - Elsevier
Schizophrenia (SZ) is a neurodevelopmental disorder with cognitive deficits manifesting
during early stages of the disease. Evidence suggests that genetic factors in combination …
during early stages of the disease. Evidence suggests that genetic factors in combination …
The gut microbiota promotes the pathogenesis of schizophrenia via multiple pathways
X Yuan, Y Kang, C Zhuo, XF Huang, X Song - Biochemical and biophysical …, 2019 - Elsevier
Schizophrenia is a severe mental disorder with unknown etiology. Many mechanisms,
including dysregulation of neurotransmitters, immune disturbance, and abnormal …
including dysregulation of neurotransmitters, immune disturbance, and abnormal …
[HTML][HTML] The role of microbiota in the pathogenesis of schizophrenia and major depressive disorder and the possibility of targeting microbiota as a treatment option
F Lv, S Chen, L Wang, R Jiang, H Tian, J Li, Y Yao… - Oncotarget, 2017 - ncbi.nlm.nih.gov
The importance of interactions between the brain and the gastrointestinal tract has been
increasingly recognized in recent years. It has been proposed that dysregulation and …
increasingly recognized in recent years. It has been proposed that dysregulation and …
Anti-anxiety and antidepressant-like effects of astragaloside IV and saponins extracted from Astragalus spinosus against the bisphenol A-induced motor and cognitive …
HTAE Abd Elkader, HM Abdou, OA Khamiss… - … Science and Pollution …, 2021 - Springer
Bisphenol A (BPA) is a chemical endocrine disruptor to which humans are often exposed in
daily life. Postnatal administration of BPA results in schizophrenia (SCZ)-like behaviours in …
daily life. Postnatal administration of BPA results in schizophrenia (SCZ)-like behaviours in …
Epigenetic mechanisms underlying NMDA receptor hypofunction in the prefrontal cortex of juvenile animals in the MAM model for schizophrenia
Y Gulchina, SJ Xu, MA Snyder… - Journal of …, 2017 - Wiley Online Library
Schizophrenia (SCZ) is characterized not only by psychosis, but also by working memory
and executive functioning deficiencies, processes that rely on the prefrontal cortex (PFC) …
and executive functioning deficiencies, processes that rely on the prefrontal cortex (PFC) …
Exploring the potential of probiotics and prebiotics in major depression: from molecular function to clinical therapy
X Yuan, J Chai, W Xu, Y Zhao - Probiotics and Antimicrobial Proteins, 2024 - Springer
Major depressive disorder (MDD) represents a complex and challenging mental health
condition with multifaceted etiology. Recent research exploring the gut-brain axis has shed …
condition with multifaceted etiology. Recent research exploring the gut-brain axis has shed …
A novel variant in TAF1 affects gene expression and is associated with X-linked TAF1 intellectual disability syndrome
We investigated the genome of a 5-year-old male who presented with global developmental
delay (motor, cognitive, and speech), hypotonia, possibly ataxia, and cerebellar hypoplasia …
delay (motor, cognitive, and speech), hypotonia, possibly ataxia, and cerebellar hypoplasia …
Juvenile treatment with mGluR2/3 agonist prevents schizophrenia-like phenotypes in adult by acting through GSK3β
Prodromal memory deficits represent an important marker for the development of
schizophrenia (SZ), in which glutamatergic hypofunction occurs in the prefrontal cortex …
schizophrenia (SZ), in which glutamatergic hypofunction occurs in the prefrontal cortex …