Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix,
where they interact with a plethora of ligands. Over the last decade, new insights have …

The cardiac extracellular matrix (ECM) is a complex architectural network consisting of
structural and nonstructural proteins, creating strength and plasticity. The nonstructural …

Basement membranes (BMs) are ubiquitous extracellular matrices whose composition
remains elusive, limiting our understanding of BM regulation and function. By developing a …

The extracellular matrix (ECM) of the developing heart contains numerous molecules that
form a dynamic environment that plays an active and crucial role in the regulation of cellular …

BACKGROUND: Heart failure, characterized by cardiac remodeling, is associated with
abnormal epigenetic processes and aberrant gene expression. Here, we aimed to elucidate …

The extracellular matrix proteoglycan (ECM) perlecan, also known as heparan sulfate
proteoglycan 2 or HSPG2, is one of the largest (> 200 nm) and oldest (> 550 M years) …

The cardiac extracellular matrix (ECM) provides a platform for cells to maintain structure and
function, which in turn maintains tissue function. In response to injury, the ECM undergoes …

Proteoglycans are a diverse group of molecules which are characterized by a central protein
backbone that is decorated with a variety of linear sulfated glycosaminoglycan side chains …

Heparan sulfate proteoglycan 2 (HSPG2) is an essential, highly conserved gene whose
expression influences many developmental processes including the formation of the heart …

Despite significant advances in treating heart disease, heart failure remains a major cause
of morbidity and mortality. Regardless of the initiating cause (s), heart failure is associated …