Exploitation of Bacillus subtilis as a robust workhorse for production of heterologous proteins and beyond
W Cui, L Han, F Suo, Z Liu, L Zhou, Z Zhou - World Journal of Microbiology …, 2018 - Springer
Bacillus subtilis, belonging to the type species of Bacillus, is a type of soil-derived, low% G+
C, endospore-forming Gram-positive bacterium. After the discovery of B. subtilis 168 that …
C, endospore-forming Gram-positive bacterium. After the discovery of B. subtilis 168 that …
Production of recombinant proteins in Bacillus subtilis
W Schumann - Advances in applied microbiology, 2007 - Elsevier
Publisher Summary The classical way of protein purification starting from a large number of
cells producing the protein using its authentic expression signals has been replaced by …
cells producing the protein using its authentic expression signals has been replaced by …
Oral vaccines: A better future of immunization
KWY Kwong, Y Xin, NCY Lai, JCC Sung, KC Wu… - Vaccines, 2023 - mdpi.com
Oral vaccines are gaining more attention due to their ease of administration, lower
invasiveness, generally greater safety, and lower cost than injectable vaccines. This review …
invasiveness, generally greater safety, and lower cost than injectable vaccines. This review …
[PDF][PDF] Improving protein production on the level of regulation of both expression and secretion pathways in Bacillus subtilis
Y Song, JM Nikoloff, D Zhan - Journal of microbiology and …, 2015 - koreascience.kr
The well-characterized gram-positive bacterium Bacillus subtilis is an outstanding industrial
candidate for protein expression owing to its single membrane and high capacity of …
candidate for protein expression owing to its single membrane and high capacity of …
Bacillus subtilis spores: A novel microparticle adjuvant which can instruct a balanced Th1 and Th2 immune response to specific antigen
AGC Barnes, V Cerovic, PS Hobson… - European journal of …, 2007 - Wiley Online Library
There is a current need for safe, cheap, and effective vaccine adjuvants, to combine with sub‐
unit antigens to enhance their immunogenicity. In this study we have used probiotic Bacillus …
unit antigens to enhance their immunogenicity. In this study we have used probiotic Bacillus …
Gut adhesive Bacillus subtilis spores as a platform for mucosal delivery of antigens
M Tavares Batista, RD Souza, JD Paccez… - Infection and …, 2014 - Am Soc Microbiol
Bacillus subtilis spores have been used as safe and heat-resistant antigen delivery vectors.
Nonetheless, the oral administration of spores typically induces weak immune responses to …
Nonetheless, the oral administration of spores typically induces weak immune responses to …
Fusion proteins, recombinant bacteria, and methods for using recombinant bacteria
B Thompson, A Siegel - US Patent 9,845,342, 2017 - Google Patents
2023-01-23 Assigned to GENISYS CREDIT UNION reassignment GENISYS CREDIT UNION
SECURITY INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: ELEMENTAL …
SECURITY INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: ELEMENTAL …
Comparative genomics analysis and transposon mutagenesis provides new insights into high menaquinone-7 biosynthetic potential of Bacillus subtilis natto
C Jiang, G Zhao, H Wang, W Zheng, R Zhang, L Wang… - Gene, 2024 - Elsevier
Abstract This research combined Whole-Genome sequencing, intraspecific comparative
genomics and transposon mutagenesis to investigate the menaquinone-7 (MK-7) synthesis …
genomics and transposon mutagenesis to investigate the menaquinone-7 (MK-7) synthesis …
Comparison of a Regulated Delayed Antigen Synthesis System with In Vivo-Inducible Promoters for Antigen Delivery by Live Attenuated Salmonella Vaccines
Induction of strong immune responses against a vectored antigen in hosts immunized with
live attenuated Salmonella vaccines is related in part to the amount of antigen delivered and …
live attenuated Salmonella vaccines is related in part to the amount of antigen delivered and …
Evaluation of different promoter sequences and antigen sorting signals on the immunogenicity of Bacillus subtilis vaccine vehicles
Recombinant Bacillus subtilis strains, either in the form of spores or vegetative cells, may be
employed as safe and low-cost vaccine vehicles. In this study, we studied the role of …
employed as safe and low-cost vaccine vehicles. In this study, we studied the role of …