Host–microbiota interactions in immune-mediated diseases

WE Ruff, TM Greiling, MA Kriegel - Nature Reviews Microbiology, 2020 - nature.com
Host–microbiota interactions are fundamental for the development of the immune system.
Drastic changes in modern environments and lifestyles have led to an imbalance of this …

The non-canonical NF-κB pathway in immunity and inflammation

SC Sun - Nature reviews immunology, 2017 - nature.com
The nuclear factor-κB (NF-κB) family of transcription factors is activated by canonical and
non-canonical signalling pathways, which differ in both signalling components and …

IgA nephropathy

E Stamellou, C Seikrit, SCW Tang, P Boor… - Nature Reviews …, 2023 - nature.com
IgA nephropathy (IgAN), the most prevalent primary glomerulonephritis worldwide, carries a
considerable lifetime risk of kidney failure. Clinical manifestations of IgAN vary from …

Efficacy and safety of a targeted-release formulation of budesonide in patients with primary IgA nephropathy (NefIgArd): 2-year results from a randomised phase 3 trial

R Lafayette, J Kristensen, A Stone, J Floege, V Tesař… - The Lancet, 2023 - thelancet.com
Background IgA nephropathy is a chronic immune-mediated kidney disease and a major
cause of kidney failure worldwide. The gut mucosal immune system is implicated in its …

[HTML][HTML] Recirculating intestinal IgA-producing cells regulate neuroinflammation via IL-10

OL Rojas, AK Pröbstel, EA Porfilio, AA Wang… - Cell, 2019 - cell.com
Plasma cells (PC) are found in the CNS of multiple sclerosis (MS) patients, yet their source
and role in MS remains unclear. We find that some PC in the CNS of mice with experimental …

IgA nephropathy

JC Rodrigues, M Haas, HN Reich - Clinical Journal of the …, 2017 - journals.lww.com
IgA nephropathy (IgAN) is a leading cause of CKD and renal failure. Recent international
collaborative efforts have led to important discoveries that have improved our understanding …

The mucosal immune system and IgA nephropathy

L Gesualdo, V Di Leo, R Coppo - Seminars in immunopathology, 2021 - Springer
The precise pathogenesis of immunoglobulin A nephropathy (IgAN) is still not clearly
established but emerging evidence confirms a pivotal role for mucosal immunity. This review …

[HTML][HTML] Management and treatment of glomerular diseases (part 1): conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies …

J Floege, SJ Barbour, DC Cattran, JJ Hogan… - Kidney international, 2019 - Elsevier
The Kidney Disease: Improving Global Outcomes (KDIGO) initiative organized a
Controversies Conference on glomerular diseases in November 2017. The conference …

Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens

K Kiryluk, Y Li, F Scolari, S Sanna-Cherchi, M Choi… - Nature …, 2014 - nature.com
We performed a genome-wide association study (GWAS) of IgA nephropathy (IgAN), the
most common form of glomerulonephritis, with discovery and follow-up in 20,612 individuals …

NF-κB in inflammation and renal diseases

H Zhang, SC Sun - Cell & bioscience, 2015 - Springer
Nuclear factor κB (NF-κB) is a family of inducible transcription factors that plays a vital role in
different aspects of immune responses. NF-κB is normally sequestered in the cytoplasm as …