Pregnancy induces a number of immunological, hormonal, and metabolic changes that are
necessary for the mother to adapt her body to this new physiological situation. The …

Exhaled breath contains thousand metabolites and volatile organic compounds (VOCs) that
originated from both respiratory tract and internal organ systems and their microbiomes …

Importance Growing interest in microbial dysbiosis during critical illness has raised
questions about the therapeutic potential of microbiome modification with probiotics. Prior …

Objective To identify research priorities in the management, epidemiology, outcome and
underlying causes of sepsis and septic shock. Design A consensus committee of 16 …

Sepsis is defined as a dysregulated host response to infection that leads to life-threatening
acute organ dysfunction. It afflicts approximately 50 million people worldwide annually and …

The gastrointestinal tract has long been hypothesized to function as “the motor” of multiple
organ dysfunction syndrome. The gastrointestinal microenvironment is comprised of a single …

Objective: To study incidence, type, etiology, risk factors, and impact on outcome of
nosocomial infections during extracorporeal membrane oxygenation. Design: Retrospective …

Rationale: Host inflammatory responses have been strongly associated with adverse
outcomes in critically ill patients, but the biologic underpinnings of such heterogeneous …

The gut microbiome is a complex microbial community, recognized for its potential role in
physiology, health, and disease. The available evidence supports the role of gut dysbiosis in …

Background Culture-based microbiological investigation of hospital-acquired or ventilator-
associated pneumonia (HAP or VAP) is insensitive, with aetiological agents often …