The immunostimulatory nature of mRNA lipid nanoparticles
Abstract mRNA-Lipid nanoparticles (LNPs) are at the forefront of global medical research.
With the development of mRNA-LNP vaccines to combat the COVID-19 pandemic, the …
With the development of mRNA-LNP vaccines to combat the COVID-19 pandemic, the …
Innate immune mechanisms of mRNA vaccines
The lipid nanoparticle (LNP)-encapsulated, nucleoside-modified mRNA platform has been
used to generate safe and effective vaccines in record time against COVID-19. Here, we …
used to generate safe and effective vaccines in record time against COVID-19. Here, we …
Considerations on the design of lipid-based mRNA vaccines against cancer
Throughout the last decades, mRNA vaccines have been developed as a cancer
immunotherapeutic and the technology recently gained momentum during the COVID-19 …
immunotherapeutic and the technology recently gained momentum during the COVID-19 …
mRNA nanodelivery systems: targeting strategies and administration routes
M Yuan, Z Han, Y Liang, Y Sun, B He… - Biomaterials …, 2023 - spj.science.org
With the great success of coronavirus disease (COVID-19) messenger ribonucleic acid
(mRNA) vaccines, mRNA therapeutics have gained significant momentum for the prevention …
(mRNA) vaccines, mRNA therapeutics have gained significant momentum for the prevention …
Advanced technologies for the development of infectious disease vaccines
Vaccines play a critical role in the prevention of life-threatening infectious disease. However,
the development of effective vaccines against many immune-evading pathogens such as …
the development of effective vaccines against many immune-evading pathogens such as …
Immune responses related to the immunogenicity and reactogenicity of COVID-19 mRNA vaccines
T Matsumura, T Takano… - International Immunology, 2023 - academic.oup.com
Vaccination for the prevention of severe acute respiratory syndrome coronavirus type 2
(SARS-CoV-2) infection is considered the most promising approach to control the pandemic …
(SARS-CoV-2) infection is considered the most promising approach to control the pandemic …
COVID-19 modified mRNA “vaccines”: Lessons learned from clinical trials, mass vaccination, and the bio-pharmaceutical complex, Part 2
MN Mead, S Seneff, J Rose, R Wolfinger… - International Journal of …, 2024 - ijvtpr.com
The COVID-19 modified mRNA (modmRNA) lipid nanoparticle-based “vaccines” are not
classical antigen-based vaccines but instead prodrugs informed by gene therapy …
classical antigen-based vaccines but instead prodrugs informed by gene therapy …
Durable cross-protective neutralizing antibody responses elicited by lipid nanoparticle-formulated SARS-CoV-2 mRNA vaccines
The advent of SARS-CoV-2 variants with defined mutations that augment pathogenicity
and/or increase immune evasiveness continues to stimulate global efforts to improve …
and/or increase immune evasiveness continues to stimulate global efforts to improve …
Genome‐wide association studies of response and side effects to the BNT162b2 vaccine in Italian healthcare workers: Increased antibody levels and side effects in …
The remarkable variability of response to vaccines against SARS‐CoV‐2 is apparent. The
present study aims to estimate the extent to which the host genetic background contributes …
present study aims to estimate the extent to which the host genetic background contributes …
[HTML][HTML] Single-epitope T cell–based vaccine protects against SARS-CoV-2 infection in a preclinical animal model
Currently authorized COVID-19 vaccines induce humoral and cellular responses to epitopes
in the SARS-CoV-2 spike protein, though the relative roles of antibodies and T cells in …
in the SARS-CoV-2 spike protein, though the relative roles of antibodies and T cells in …