Brain tumors, although rare, contribute to distinct mortality and morbidity at all ages.
Although there are few therapeutic options for brain tumors, enhanced biological …

The management of primary CNS lymphoma is one of the most controversial topics in neuro-
oncology because of the complexity of the disease and the very few controlled studies …

Primary central nervous system lymphomas (PCNSLs) and primary testicular lymphomas
(PTLs) are extranodal large B-cell lymphomas (LBCLs) with inferior responses to current …

PURPOSE Clinical outcomes of patients with CNS lymphomas (CNSLs) are remarkably
heterogeneous, yet identification of patients at high risk for treatment failure is challenging …

Primary lymphomas of the central nervous system (PCNSL) are mainly diffuse large B-cell
lymphomas (DLBCLs) confined to the central nervous system (CNS). Molecular drivers of …

Background Primary central nervous system lymphomas (PCNSLs) are mainly diffuse large
B-cell lymphomas (DLBCLs) of the non-germinal centre B-cell subtype, with unmet medical …

Diffuse large B-cell lymphoma (DLBCL) is a genetically heterogeneous cancer composed of
at least 2 molecular subtypes that differ in gene expression and distribution of mutations …

Purpose: In cancer cells, the epigenome is often deregulated, and inhibition of the
bromodomain and extra-terminal (BET) family of bromodomain-containing proteins is a …

Primary central nervous system lymphoma (PCNSL) is a rare form of non-Hodgkin
lymphoma that affects the brain parenchyma, spinal cord, eyes, and cerebrospinal fluid …

Purpose: Oncogenic fusions consisting of fibroblast growth factor receptor (FGFR) and
TACC are present in a subgroup of glioblastoma (GBM) and other human cancers and have …