Strategies of targeting CK2 in drug discovery: challenges, opportunities, and emerging prospects
Y Chen, Y Wang, J Wang, Z Zhou, S Cao… - Journal of Medicinal …, 2023 - ACS Publications
CK2 (casein kinase 2) is a serine/threonine protein kinase that is ubiquitous in eukaryotic
cells and plays important roles in a variety of cellular functions, including cell growth …
cells and plays important roles in a variety of cellular functions, including cell growth …
Palladium‐Catalyzed Tandem Cyclization of 2‐(2 Ethynylphenyl)acetonitriles and Isocyanides: Access to Indeno[2,1‐b]pyrroles
HS Lin, YZ Pan, YH Tian, YM Pan… - Advanced Synthesis & …, 2022 - Wiley Online Library
A palladium‐catalyzed tandem cyclization of 2‐(2‐ethynylphenyl) acetonitriles with
isocyanides has been developed. Various indeno [2, 1‐b] pyrroles were prepared in 55 …
isocyanides has been developed. Various indeno [2, 1‐b] pyrroles were prepared in 55 …
Synthesis of Indenoindole Derivatives under Deep Eutectic Solvent Conditions
In this study, we synthesized a variety of indole derivatives using commercially available 2, 5‐
dimethoxybenzaldehyde 18 as a starting material. The synthetic route involves a sequential …
dimethoxybenzaldehyde 18 as a starting material. The synthetic route involves a sequential …
4,5,7‐Trisubstituted indeno[1,2‐b]indole inhibits CK2 activity in tumor cells equivalent to CX‐4945 and shows strong anti‐migratory effects
R Birus, E El‐Awaad, L Ballentin, F Alchab… - FEBS Open …, 2022 - Wiley Online Library
Highly pleiotropic and constitutively active protein kinase CK2 is a key target in cancer
therapy, but only one small‐molecule inhibitor has reached clinical trials—CX‐4945. In this …
therapy, but only one small‐molecule inhibitor has reached clinical trials—CX‐4945. In this …
Catalyst-free direct synthesis of indeno[1,2-b]indol-5(4bH)-yl benzimidamides
MAM Gomaa, DK Hassan - Zeitschrift für Naturforschung B, 2023 - degruyter.com
A new series of indeno [1, 2-b] indol-5 (4b H)-ylbenzimidamide derivatives 3a–3j has been
synthesized as potential casein kinase II (CK2) inhibitors. A convenient and straightforward …
synthesized as potential casein kinase II (CK2) inhibitors. A convenient and straightforward …
Meglumine Sulfate as an Effective Catalyst for the Preparation of some Indeno [1, 2-b] indole-9, 10-dione Derivatives
A Moazeni Bistgani, L Moradi - Organic Chemistry Research, 2023 - orgchemres.org
Aligned with advancements in synthetic chemistry, this work presents the synthesis and
characterization of meglumine sulfate using FT-IR and CHNS analysis. Subsequently, the …
characterization of meglumine sulfate using FT-IR and CHNS analysis. Subsequently, the …