Anaplastic lymphoma kinase (ALK) is a validated molecular target in several ALK-
rearranged malignancies, including non–small cell lung cancer. However, the clinical …

The burgeoning field of anaplastic lymphoma kinase (ALK) in cancer encompasses many
cancer types, from very rare cancers to the more prevalent non-small-cell lung cancer …

Purpose Fusions involving the ALK gene are the predominant genetic lesion underlying
pediatric anaplastic large cell lymphomas (ALCL) and inflammatory myofibroblastic tumors …

Spitzoid neoplasms are a group of melanocytic tumours with distinctive histopathological
features. They include benign tumours (Spitz naevi), malignant tumours (spitzoid …

(1) Background: The oncology field has drastically changed with the advent of precision
medicine, led by the discovery of druggable genes or immune targets assessed through next …

Inflammatory myofibroblastic tumor (IMT) is a distinctive mesenchymal neoplasm
characterized by a spindle-cell proliferation with an inflammatory infiltrate. Approximately …

Approximately 50% of conventional inflammatory myofibroblastic tumors (IMTs) harbor ALK
gene rearrangement and overexpress ALK. Recently, gene fusions involving other kinases …

In 2007, scientists discovered that anaplastic lymphoma kinase (ALK) gene rearrangements
are present in a small subset of non–small-cell lung cancers. ALK-positive cancers are …

Pathology and Genetics of Head and Neck Tumoursis the latest volume in the new WHO
series, on histological and genetic typing of human tumours. This authoritative, concise …

Anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKI), including crizotinib, are
effective treatments in preclinical models and in cancer patients with ALK-translocated …