This article will provide an updated review of spermatogonial stem cells and their role in
maintaining the spermatogenic lineage. Experimental tools used to study spermatogonial …

The number of men surviving cancer at a young age has increased dramatically in the past
20 years as a result of early detection and improved cancer treatment protocols; more than …

BACKGROUND Fertility in adult life may be severely impaired by gonadotoxic therapies. For
young boys who do not yet produce spermatozoa, cryopreservation of immature testicular …

This review looks into the phylogeny of spermatogonial stem cells and describes their basic
biological features. We are focusing on species-specific differences of spermatogonial stem …

Objective To determine the molecular characteristics of human spermatogonia and optimize
methods to enrich spermatogonial stem cells (SSCs). Design Laboratory study using human …

The testis has been shown to be highly susceptible to the toxic effects of cancer therapy at
all stages of life. Young cancer survivors are approximately half as likely as their siblings to …

Spermatogonial stem cells (SSCs) maintain spermatogenesis throughout the reproductive
life of mammals. While Asingle spermatogonia comprise the rodent SSC pool, the identity of …

Culture and differentiation of male germ cells has been performed for various purposes in
the past. To date, none of the studies aimed at in vitro spermatogenesis has resulted in a …

Male germline stem cells—spermatogonial stem cells (SSCs)—self-renew and produce
large numbers of differentiating germ cells that become spermatozoa throughout postnatal …

BACKGROUND Fertility preservation has become an urgent clinical requisite for prepubertal
male cancer patients undergoing gonadotoxic treatment. As these patients do not yet …