Immunosuppressive regulatory T cells (Tregs) provide a main mechanism of tumor immune
evasion. Targeting Tregs, especially in the tumor microenvironment (TME), continues to be …

T-regulatory cells (Tregs) are found infiltrating tumors in a vast array of tumor types, and
tumor-infiltrating Tregs are often associated with a poor clinical outcome. Tregs are potent …

The actions of the immune system are finely tuned, involving complex communication and
coordination between diverse immune and non-immune cells across the tissues of the body …

Emerging evidence indicates that angiogenesis and immunosuppression frequently occur
simultaneously in response to diverse stimuli. Here, we describe a fundamental biological …

Tumors evade immune destruction by actively inducing immune tolerance through the
recruitment of CD4+ CD25+ Foxp3+ regulatory T cells (Treg). We have previously described …

Regulatory T (Treg) cells play a crucial role in maintaining peripheral tolerance and
preventing autoimmunity. However, they also represent a major barrier to effective antitumor …

Breast cancer, rather than constituting a monolithic entity, comprises heterogeneous tumors
with different clinical characteristics, disease courses, and responses to specific treatments …

Infiltration of Foxp3+ regulatory T (T reg) cells is considered to be a critical step during tumor
development and progression. T reg cells supposedly suppress locally an effective anti …

Endothelial-immune cell cross-talk goes well beyond leukocyte and lymphocyte trafficking,
since immune cells are able to intimately regulate vessel formation and function. Here we …

We investigated the clinical significance of tumour-infiltrating FOXP3-positive regulatory T
cells (Tregs) in radically resected (R0) gastric cancer. From a single-institution database …