A comprehensive review on β-lapachone: Mechanisms, structural modifications, and therapeutic potentials
Q Gong, J Hu, P Wang, X Li, X Zhang - European Journal of Medicinal …, 2021 - Elsevier
Abstract β-Lapachone (β-lap, 1), an ortho-naphthoquinone natural product isolated from the
lapacho tree (Tabebuia avellanedae) in many regions of South America, has received …
lapacho tree (Tabebuia avellanedae) in many regions of South America, has received …
Beta-lapachone: Natural occurrence, physicochemical properties, biological activities, toxicity and synthesis
CL Gomes, VAW Sales, CG de Melo, RMF da Silva… - Phytochemistry, 2021 - Elsevier
Abstract β-Lapachone is an ortho-naphthoquinone originally isolated from the heartwood of
Handroanthus impetiginosus and can be obtained through synthesis from lapachol …
Handroanthus impetiginosus and can be obtained through synthesis from lapachol …
Anticancer potential of resveratrol, β-lapachone and their analogues
DC Ferraz da Costa, L Pereira Rangel… - Molecules, 2020 - mdpi.com
This review aims to explore the potential of resveratrol, a polyphenol stilbene, and beta-
lapachone, a naphthoquinone, as well as their derivatives, in the development of new drug …
lapachone, a naphthoquinone, as well as their derivatives, in the development of new drug …
Synthesis of quinones with highlighted biological applications: A critical update on the strategies towards bioactive compounds with emphasis on lapachones
EN da Silva Júnior, GAM Jardim, C Jacob… - European Journal of …, 2019 - Elsevier
Naphthoquinones are of key importance in organic synthesis and medicinal chemistry. In the
last few years, various synthetic routes have been developed to prepare bioactive …
last few years, various synthetic routes have been developed to prepare bioactive …
Cancer metabolism control by natural products: Pyruvate kinase M2 targeting therapeutics
AH El‐Far, SK Al Jaouni, X Li, J Fu - Phytotherapy Research, 2022 - Wiley Online Library
Glycolysis is the primary source of energy for cancer growth and metastasis. The shift in
metabolism from mitochondrial oxidative phosphorylation to aerobic glycolysis is called the …
metabolism from mitochondrial oxidative phosphorylation to aerobic glycolysis is called the …
[HTML][HTML] Ball-milled graphene quantum dots for enhanced anti-cancer drug delivery
Graphene quantum dots (GQDs) exhibit excellent opto-electronic properties along with fine-
tunable structure and surface properties, which have made them versatile drug carriers …
tunable structure and surface properties, which have made them versatile drug carriers …
Glycine catalyzed one-pot three-component synthesis of structurally diverse 2-amino substituted pyran annulated heterocycles in aqueous ethanol under refluxed …
B Banerjee, M Kaur, A Sharma, A Singh… - Current Green …, 2022 - ingentaconnect.com
Introduction: A facile, convenient and general method has been developed for the one-pot
three-component synthesis of structurally diverse 2-amino pyran annulated heterocycles …
three-component synthesis of structurally diverse 2-amino pyran annulated heterocycles …
Probing the influence of defects and Si-doping in graphene sheet as an efficacious carrier for drug delivery system in gas and aqua phases-Combined DFT and …
D Arumugam, M Subramani, R Durai… - Journal of Physics and …, 2023 - Elsevier
In this study, for the bioavailability and distribution of the drug on the tumor cells we have
chosen targeted drug delivery system and for the delivery system, pristine, defected, and …
chosen targeted drug delivery system and for the delivery system, pristine, defected, and …
Lapachol inhibits glycolysis in cancer cells by targeting pyruvate kinase M2
M Shankar Babu, S Mahanta, AJ Lakhter, T Hato… - PloS one, 2018 - journals.plos.org
Reliance on aerobic glycolysis is one of the hallmarks of cancer. Although pyruvate kinase
M2 (PKM2) is a key mediator of glycolysis in cancer cells, lack of selective agents that target …
M2 (PKM2) is a key mediator of glycolysis in cancer cells, lack of selective agents that target …
[HTML][HTML] The plant-derived naphthoquinone lapachol causes an oxidative stress response in Staphylococcus aureus
Staphylococcus aureus is a major human pathogen, which causes life-threatening systemic
and chronic infections and rapidly acquires resistance to multiple antibiotics. Thus, new …
and chronic infections and rapidly acquires resistance to multiple antibiotics. Thus, new …